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临床试验/NCT01735734
NCT01735734Unknown不适用

An Observational Study as to the Effects of Cutaneous Air-cooling on Blood Vessel Diameter in Capillary Malformations

National Health Service, United Kingdom1 个研究点 分布在 1 个国家目标入组 35 人开始时间: 2013年2月最近更新:
适应症

试验速览

阶段
不适用
发起方
入组人数
35
试验地点
1
主要终点
To study the effects of cutaneous air cooling on blood vessel diameter in capillary malformation

研究概览

简要总结

The purpose of this observational study is to ascertain the effects of cutaneous air cooling on vessel diameter within Capillary Malformations (CM).

详细描述

Capillary malformation (CM) is the most common vascular malformation occurring in approximately 0.3% of all newborn. The standard treatment for facial or aesthetically sensitive CM's is flashlamp Pulsed Dye Laser. Skin cooling prior to laser treatment of CMs is standard practice within our department. The effects of skin cooling on the vasculature within CMs are poorly understood. Previous studies by our department have shown that raising ambient temperature increases CM vessel size. It has been postulated that by increasing CM vessel size, it may also increase the effectiveness of treatment. We hypothesize that cooling the skin during laser treatment may cause vasconstriction of the superficial vessels within the CM. This may have an impact on treatment success.

研究设计

研究类型
Observational
观察模型
Case Only
时间视角
Prospective

入排标准

年龄范围
16 Years 至 —(Child, Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Adult more than 16 years of age
  • Patient diagnosed with Capillary Malformation

排除标准

  • Patients less than 16 years of age

结局指标

主要结局

To study the effects of cutaneous air cooling on blood vessel diameter in capillary malformation

时间窗: 10 minutes

In a temperature controlled room, the participant's capillary diameter/depth and skin/core temperatures will be taken from their CM prior to cooling the skin. The patients' CM will be cooled for a duration of 1 minute. The above measurements will be repeated immediately after 1 minute of cooling.

次要结局

未报告次要终点

研究者

发起方
National Health Service, United Kingdom
申办方类型
Other Gov
责任方
Principal Investigator
主要研究者

Dr Irving Ling

Academic Foundation Doctor, Honorary Clinical Fellow

NHS Greater Glasgow and Clyde

研究点 (1)

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