An Observational Study as to the Effects of Cutaneous Air-cooling on Blood Vessel Diameter in Capillary Malformations
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Enrollment
- 35
- Locations
- 1
- Primary Endpoint
- To study the effects of cutaneous air cooling on blood vessel diameter in capillary malformation
Study Overview
Brief Summary
The purpose of this observational study is to ascertain the effects of cutaneous air cooling on vessel diameter within Capillary Malformations (CM).
Detailed Description
Capillary malformation (CM) is the most common vascular malformation occurring in approximately 0.3% of all newborn. The standard treatment for facial or aesthetically sensitive CM's is flashlamp Pulsed Dye Laser. Skin cooling prior to laser treatment of CMs is standard practice within our department. The effects of skin cooling on the vasculature within CMs are poorly understood. Previous studies by our department have shown that raising ambient temperature increases CM vessel size. It has been postulated that by increasing CM vessel size, it may also increase the effectiveness of treatment. We hypothesize that cooling the skin during laser treatment may cause vasconstriction of the superficial vessels within the CM. This may have an impact on treatment success.
Study Design
- Study Type
- Observational
- Observational Model
- Case Only
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 16 Years to — (Child, Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Adult more than 16 years of age
- •Patient diagnosed with Capillary Malformation
Exclusion Criteria
- •Patients less than 16 years of age
Outcomes
Primary Outcomes
To study the effects of cutaneous air cooling on blood vessel diameter in capillary malformation
Time Frame: 10 minutes
In a temperature controlled room, the participant's capillary diameter/depth and skin/core temperatures will be taken from their CM prior to cooling the skin. The patients' CM will be cooled for a duration of 1 minute. The above measurements will be repeated immediately after 1 minute of cooling.
Secondary Outcomes
No secondary outcomes reported
Investigators
Dr Irving Ling
Academic Foundation Doctor, Honorary Clinical Fellow
NHS Greater Glasgow and Clyde