Colonoscopic surveillance using narrow-band imaging in patients with hyperplastic polyposis syndrome (HPS)
- Conditions
- polypstumor1001801810017990
- Registration Number
- NL-OMON30966
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 33
Inclusion Criteria
All patients presenting, or under surveillance at the Endoscopy Department of the AMC with:
1) *10 HPs found at colonoscopy, or
2) *5 HPs proximal to the sigmoid colon, or
3) Any number of HPs occurring proximal to sigmoid colon in an individual who has a first-degree relative with HPS
Exclusion Criteria
1) history of inflammatory bowel disease, 2) severe coagulopathy, 3) age less than 18 years and 4) insufficient bowel preparation (<90% of colonic mucosa visible).
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The sensitivity of WLE will be compared to that of NBI for the detection of<br /><br>polyps and cancer in the colon. The sensitivity of each technique will be<br /><br>calculated as the number of lesions detected during the first inspection,<br /><br>divided by the total number of lesions detected by both inspections.<br /><br>Furthermore, the surface pit pattern of the detected lesions on NBI will be<br /><br>used to obtain the overall accuracy (representing sensitivity and specificity)<br /><br>of this technique, by using the histological diagnosis as the gold standard<br /><br>diagnosis. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Moreover, the prevalence and distribution of HPs, SAs, MPs and adenomas in this<br /><br>patient population will be described.</p><br>