Intra Uterine Extra Amniotic (200 μg ) Versus Vaginal (200 μg) Misoprostol for Second Trimester Pregnancy Termination: Randomized Controlled Trial
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 180
- 主要终点
- mean duration from the initial misoprostol dose until complete fetal expulsion
研究概览
简要总结
The majority of second-trimester pregnancy termination performed in the United States are performed surgically by dilation and evacuation. The frequency of induction of abortion increases as gestational age advances. In the late second trimester and early third trimester, induction is the primary method of termination in cases of fetal abnormalities. In many other countries, however, induction is the primary method of abortion throughout the second trimester
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Pregnancy 13-24 weeks.
- •Women with indication for termination of the pregnancy due to intra uterine fetal death
排除标准
- •Pregnancy before 13 weeks.
- •Pregnancy beyond 24 weeks.
- •Women with scared uterus.
- •Known hypersensitivity for misoprostol.
- •Refusal of the woman to participate.
研究组 & 干预措施
extra amniotic misoprostol
misoprostol dissolved in warm saline , become dissolute misoprostol saline solution(200 microgram every 4 hours)
干预措施: termination of second trimester pregnancy (Procedure)
vaginal misoprostol
misoprostol tablet soaked with distilled water and inserted in the posterior fornix of the vagina( 200 microgram every 4 hours)
干预措施: termination of second trimester pregnancy (Procedure)
结局指标
主要结局
mean duration from the initial misoprostol dose until complete fetal expulsion
时间窗: 24 hours
次要结局
未报告次要终点
研究者
abo bakr mitwally
lecturer
Assiut University