Comparation of Ultrasonic Imaging of Enthesopathy in Patients With Psoriatic Arthritis and Psoriasis

• Conditions: Enthesopathy
• Interventions: Device: Musculoskeletal Ultrasound

• Registration Number: NCT02962271
• Lead Sponsor: Chinese PLA General Hospital

Brief Summary

Psoriatic arthritis(PsA) and psoriasis(Ps) are two systemic inflammatory diseases linked with rash of psoriasis, but there's still great controversy regarding the exact relationship between them. Our study is to investigate the characteristics and differences of the ultrasonic imaging of enthesopathy in the lower extremity in patients with PsA and Ps, to explore the risk factors of Ps developing into PsA in the long term course.

Detailed Description

As one of the most common chronic inflammatory skin diseases, psoriasis(Ps) can be intimately associated to psoriatic arthritis (PsA), affecting approximately 1% to 2% of the world's population. About 30% of them will develop into PsA with serious impact on their health-related quality of life.

PsA, characterised by different subsets with varying degree of severity, is a chronic, complicated inflammatory disease.Enthesitis is the prevalent and distinctive feature of PsA.

Musculoskeletal Ultrasound (MSUS) is a valid noninvasive modality, essential to evaluate entheses thickness, enthesophytes, bursitis and bone erosions as well as to disclose vascularisation on tendons through power doppler (PD) assessment. In recent years, more and more attention has been paid to the diagnosis and management of Ps and PsA, owing to its discrimination of identifying subclinical entheses and joint changes.

Study Timeline

• Study Start: 2016-01
• Status Verified: 2016-11
• Primary Completion: 2016-11
• Study First Submitted: 2016-11-03
• Study First Submitted QC: 2016-11-09
• Last Update Submitted: 2016-11-09
• Study First Posted: 2016-11-11
• Last Update Posted: 2016-11-11
• Study Completion: 2016-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 187

Inclusion Criteria

• Clinical diagnosis of plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, rheumatoid arthritis or osteoarthritis.
• Body Mass Index (BMI)<30 kg/m2.
• Absence of local glucocorticoid or other drugs injection or surgical treatment for entheses scanned in the previous 6 weeks prior to clinical and musculoskeletal ultrasound (MSUS) evaluation.

Exclusion Criteria

• Other systemic rheumatic diseases or malignant neoplasms.
• Peripheral neuropathy of lower extremity.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Psoriasis	Musculoskeletal Ultrasound	Musculoskeletal ultrasound (MSUS) of the lower limbs' entheses were performed
Psoriatic Arthritis	Musculoskeletal Ultrasound	Musculoskeletal ultrasound (MSUS) of the lower limbs' entheses were performed

Primary Outcome Measures

Name	Time	Method
The rate of enthesopathy comparison between psoriatic arthritis(PsA) and psoriasis(Ps) as assessed by SPSS v17.0	up to 10 months

Secondary Outcome Measures

Name	Time	Method
The potential risk factors of Ps for PsA as assessed by SPSS v17.0	up to 10 months

Trial Locations

Locations (1)

Chinese PLA General Hospital; 🇨🇳 Beijing, China