Impaired Platelet Reactivity as an Early Biomarker for Sepsis-related Thrombocytopenia

Università degli Studi di Ferrara1 site in 1 country30 target enrollmentApril 1, 2017

ConditionsSeptic Shock Thrombocytopenia Sepsis Platelet Aggregation Disseminated Intravascular Coagulation

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Septic Shock
Sponsor: Università degli Studi di Ferrara
Enrollment: 30
Locations: 1
Primary Endpoint: Occurence of sepsis-induced thrombocytopenia
Status: Completed
Last Updated: 7 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Coagulation disorders and thrombocytopenia are common in patients with septic shock. Despite the clinical relevance of sepsis-induced thrombocytopenia, few studies have focused on the prediction of thrombocytopenia in this setting. The aim of this study was to evaluate whether platelets aggregometry and markers of platelets activation, such as mean platelet volume or platelet volume distribution width, could predict sepsis-induced thrombocytopenia in patients with septic shock and normal platelet count on the day of diagnosis.

Registry

clinicaltrials.gov

Start Date

April 1, 2017

End Date

August 30, 2018

Last Updated

7 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Università degli Studi di Ferrara

Responsible Party

Principal Investigator

Alberto Fogagnolo

Università degli Studi di Ferrara

Eligibility Criteria

Inclusion Criteria

•diagnosis of septic shock
•platelet count \>150\*103/mcL.

Exclusion Criteria

•age \<18 years
•history of any hematologic disorder
•chronic liver failure
•previous chemotherapy
•transfusion of platelet during the previous 4 weeks
•renal replacement therapy before ICU admission
•history of antiplatelet therapy during the 8 days before inclusion
•history of heparin-induced thrombocytopenia (HIT) or other acquired or induced thrombocytopenia
•occurrence of HIT (defined as HIT score over 3)
•active bleeding

Outcomes

Primary Outcomes

Occurence of sepsis-induced thrombocytopenia

Time Frame: 5 days after study inclusion

Occurence of platelet count \<150 \*103/μL

Secondary Outcomes

number of Red blood cells (RBC) packs transfused during ICU stay(After 28 days from study inclusion)
life-threatening bleeding(After 28 days from study inclusion)
90-day mortality(after 90 days from study enrollment)