The Role of Oxytocin in the Perception of Infant Faces
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 71
- 主要终点
- Functional Magnetic Resonance Imaging (fMRI) Data
研究概览
简要总结
The main objective of this project is to study whether intranasal oxytocin (OT) affects how young adults perceive and attend to infant and adult faces. Based on existing research the investigators predict that oxytocin will facilitate the allocation of attentional resources on infant faces (compared to adult faces). The investigators also predict that oxytocin will enhance the activity of reward neural-networks associated with the perception of infant faces. The behavioral effects of OT (visual attention and face recognition) will be measured with eye-tracking while participants look at photographs of adult and infant faces. Neurological effects (the activity of emotion and reward networks) will be measured with functional Magnetic Resonance Imaging (fMRI) while participants look at infant faces on a computer screen.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 25 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy Volunteers
- •Norma or corrected to norma vision
- •Participants are non parents
- •Able to provide written informed consent and to comply with all study procedures
排除标准
- •Dementia or severe cognitive disorders
- •Endocrine disease or malignancy
- •Nasal obstruction or upper-respiratory tract infection
- •Current or previous psychiatric disorder
- •Current or previous use of psychoactive drugs
- •Alcoholism or substance abuse
- •History of seizures
- •Neurological Disorder
- •Previous head trauma
- •Hypertension
- •Cardiovascular Disease
- •Claustrophobia
- •ferrous metal in any part of the body
研究组 & 干预措施
Intranasal oxytocin group
Participants will self-administer a single dose of 24 IU oxytocin (Syntocinon, Novartis; three puffs per nostril, each with 4 IU oxytocin, 6 puffs total).
干预措施: Syntocinon (synthetic oxytocin) (Drug)
Placebo group
The placebo is identical to the oxytocin formulation with the exception of the active compound.
Participants will self-administer three puffs per nostril of placebo (6 puffs total).
干预措施: Placebo (Other)
结局指标
主要结局
Functional Magnetic Resonance Imaging (fMRI) Data
时间窗: 45 minutes after OT manipulation
The effect of OT will be assessed by determining changes in brain activation between treatment and placebo groups.
Eye movements data
时间窗: 45 minutes after OT manipulation
The effect of OT will be assessed by determining changes in eye movements between treatment and placebo groups.
次要结局
- Implicit Attitudes toward infants(45 minutes after OT manipulation)
- Theory of mind(45 minutes after OT manipulation)
研究者
Rodrigo Cardenas
Lecturer
Penn State University