Magnesium Effect on Embryonal PR Interval

Not Applicable

• Conditions: Preterm Labor
• Interventions: Diagnostic Test: Trans abdominal sonography

• Registration Number: NCT03047304
• Lead Sponsor: Rambam Health Care Campus

Brief Summary

Magnesium is a known treatment for neuroprotection in preterm labor before 32 week of gestation. High concentration of Magnesium in the blood stream known as cause of conduction abnormalities and ECG changes such us prolonged QT, QRS and PR in about. The goal of our work is to evaluate the PR intervals in embryos after maternal treatment with magnesium during preterm labor.

Detailed Description

We will recruit 25 woman with threaten preterm labor, magnesium blood level and PR interval will be evaluated before magnesium loading dose (4gr) and 20 minutes after the loading dose.

PR interval will be evaluated by Mitral-Aorta Doppler.

Study Timeline

• Status Verified: 2017-02
• Study First Submitted: 2017-02-06
• Study First Submitted QC: 2017-02-06
• Study First Posted: 2017-02-08
• Last Update Submitted: 2017-02-13
• Study Start: 2017-02-14
• Last Update Posted: 2017-02-15
• Primary Completion: 2018-02-10
• Study Completion: 2018-03-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 25

Inclusion Criteria

• Women at risk for preterm labor before 32 week of gestation

Exclusion Criteria

• Fetal malformations
• Maternal Lupus
• Fetal conduction abnormalities

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Women in risk for preterm labor	Trans abdominal sonography	Women in risk for preterm labor treated with magnesium.

Primary Outcome Measures

Name	Time	Method
Prolonged PR interval	20 min after magnesium treatment	PR will be measured by Mitral-aorta doppler