MRI study of steroid-induced osteonecrosis
Not Applicable
- Conditions
- systemic lupus erythematosus and steroid-induced osteonecrosis
- Registration Number
- JPRN-UMIN000001333
- Lead Sponsor
- Department of Orthopaedic Surgery, Graduate school of Medicine, Chiba University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 120
Inclusion Criteria
Not provided
Exclusion Criteria
(1) Previous trauma and surgery (2) MRI can not undergo. (3) Unfavorable patient condition (4) Inappropriate patient
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Changes of the necrotic area were evaluated as either improved, aggravated, or unchanged. Improvement was defined as either a reduction or disappearance of osteonecrosis, with reduction defined as an improvement of more than one type of the 2001 revised criteria for classification of osteonecrosis of the femoral head of the Japanese Ministry of Health, Labor and Welfare. Aggravation was defined as enlargement of a previous osteonecrotic lesion, a new lesion, and/or collapse of osteonecrosis. Enlargement included both cases that were enlarged after reduction of the necrotic area or were reduced after enlargement. Collapse was defined as MR finding of bone marrow edema with clinical symptom of pain. Collapse included cases subsequent to enlarged or new osteonecrotic lesions. Unchanged was defined as no change of the necrotic area. A p-value less than 0.05 is considered significant using Fisher exact probability test.
- Secondary Outcome Measures
Name Time Method The total cumulative corticosteroid dose (g), mean corticosteroid dosage (mg/day), and duration of corticosteroid treatment (years) were compared between joints with and without osteonecrosis.