Study of the Causes of the Breakdown of Muscle Fibers in Hospitalized Patients

• Conditions: Rhabdomyolysis; Myopathy; Acute Renal Failure; Neuroleptic Malignant Syndrome

• Registration Number: NCT01022450
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

1. Analyze the various causes of breakdown of muscle fibers in hospitalized patients.

2. Analyze the characteristics of these patients in Taiwan (including the drugs history, risk factors and the incidence of complications).

Detailed Description

1. Find the causes of breakdown of muscle fibers in hospitalized patients through medical record review.

* especially drug-related

2. Find the risk factors of muscle fibers breakdown.

Study Timeline

• Status Verified: 2009-11
• Study Start: 2009-11
• Study First Submitted: 2009-11-25
• Study First Submitted QC: 2009-11-30
• Last Update Submitted: 2009-11-30
• Study First Posted: 2009-12-01
• Last Update Posted: 2009-12-01
• Primary Completion: 2010-11

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 2500

Inclusion Criteria

• Patients who admitted to The National Taiwan University Hospital during 2003/1/1~2008/12/31 with the following discharge diagnosis: myoglobinuria, rhabdomyolysis, myopathy, toxic myopathy, malignant hyperthermia, neuroleptic malignant syndrome, polymyositis, myalgia and had acute neuromuscular illness presentations and serum creatinine kinase (CK) more than 5 times the upper limit of normal (male > 900 IU/L; female > 835 IU/L).

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Exclusion Criteria

• Patients with recent myocardial infarction or stroke, unless clinical history, examination, or electromyography showed a concomitant myopathy.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

National Taiwan University Hospital; 🇨🇳 Taipei, Taiwan