Effect of Es-ketamine on Postoperative Delirium Among Old Patients With Lobectomy
Not Applicable
- Conditions
- Postoperative Delirium
- Registration Number
- NCT04969523
- Lead Sponsor
- Zhongnan Hospital
- Brief Summary
The purpose of this study is the efficiency of es-ketamine on postoperative delirium among old patients with elective lobectomy
- Detailed Description
This study aimed to investigate the effect of IV es-ketamine vs saline on the incidence of postoperative delirium. It was hypothesized that IV es-ketamine would reduce the incidence of in-hospital delirium during cardiac surgery lobectomy
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 500
Inclusion Criteria
- 60 years old; There is no limit on the gender, ASA (American Society of Anesthesiologists )Ⅰ-Ⅲ
Exclusion Criteria
- Emergency surgery, severe hepatic and renal dysfunction, shock or coma, psychiatric disease or central nervous system disorder or a history of long-term use of psychiatric medications, cognitive dysfunction, severe arrhythmia or bradycardia, ketamine allergy,drug abuse history and used other sedatives for nearly a week
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Postoperative Delirium 7 days after operation Confusion Assessment Method (CAM) or CAM-ICU for patients
Postoperative Cognitive Assessment 7 days after operation Montreal Cognitive Assessment
- Secondary Outcome Measures
Name Time Method