An Open-Label, Randomised, Phase 4 Study of Continuing Sodium Zirconium Cyclosilicate (SZC) After Discharge in Participants With Chronic Kidney Disease Treated for Hyperkalaemia
Overview
- Phase
- Phase 4
- Intervention
- Sodium Zirconium Cyclosilicate (SZC)
- Conditions
- Hyperkalaemia
- Sponsor
- AstraZeneca
- Enrollment
- 186
- Locations
- 1
- Primary Endpoint
- Occurrence (Yes/No) of NK (K+ Between 3.5 and 5.0 mmol/L, Inclusive) at 180 Days Post-discharge
- Status
- Completed
- Last Updated
- 5 months ago
Overview
Brief Summary
This is an open-label, randomised study in participants with chronic kidney disease (CKD) treated for hyperkalaemia (HK) whilst in hospital. The study will compare SZC to standard of care (SoC) with the goal of determining:
- If continued use of SZC maintains normokalaemia (NK) better than SoC after participant discharge from the hospital.
- If continued use of SZC after discharge will reduce HK related healthcare resource utilisation compared to SoC.
Detailed Description
This is a Phase 4, randomised, controlled, open-label, parallel-group, multicentre study in participants with CKD treated for HK whilst in hospital. * Participants from 30 to 50 sites in 4 to 7 countries will be screened for enrolment. In total, up to a maximum of 163 participants will be enrolled, resulting in approximately 130 participants discharged and randomised and 104 evaluable participants (52 per arm). * The study plans to enrol approximately equal numbers of participants with mild HK (K+ between \> 5.0 and ≤ 5.5 mmol/L) and with moderate/severe HK (K+ between \> 5.5 and ≤ 6.5 mmol/L), with a minimum of 30% of the enrolled participants in either group. * During the in-hospital phase, participants will be treated with SZC as per local label, starting at baseline and based on local K+ measurement obtained within 24 hours of treatment initiation:). * Participants with HK (K+ between \> 5.0 and ≤ 6.5 mmol/L): 1. stop current K-binder if any 2. start SZC correction dose (note: participants currently on SZC should continue SZC correction dose, up to 72 hours). * Participants currently receiving any treatment for the current episode of HK and are already NK at baseline (K+ ≤ 5.0 mmol/L): 1) stop any current K-binder, 2) start SZC maintenance dose (note: participants currently on SZC maintenance dose should continue SZC maintenance dose). * All treatment decisions, including modification of the ongoing therapy for HK must be based on the investigator's medical judgement of the participant's best interest. * At discharge, NK participants who have been treated with SZC for between 1 and 21 days whilst in hospital and are started on SZC maintenance dose will be randomised in a 1:1 ratio to one of the following arms: * Arm A: Participants discharged with SZC, as per local label, to manage HK until the end of the outpatient phase * Arm B: Participants discharged with SoC, as per local practice, to manage HK until the end of study. Note: Participants intended to be discharged with a K+ binder (as per the site routine medical practice) will not be randomised and will be discontinued from the study. Still, participants randomised into Arm B may have a K-binder prescribed at Day 7 post-discharge, (or after Day 7 post-discharge), to treat confirmed HK or in case there is an increase in K+ level since discharge that, in the investigator's opinion, requires therapy. * The total duration of the study for each participant will be up to approximately 6 months. * Study visit schedule is as follows: In-hospital phase: - The screening visit will occur while the participant is at the hospital (up to 21 days before discharge; medical monitor's approval may be sought for allowing longer duration hospital stays for specific participants) in order to check eligibility criteria * Inpatient phase: o The baseline visit (can occur the same day as the screening visit) where treatment with SZC will be initiated o The discharge visit, 1 to 20 days after baseline; medical monitor's approval may be sought for allowing longer duration hospital stays for specific participants). Randomisation will occur at day of discharge. * Outpatient phase: - Visits will occur at 7, 30, 60, 90, 120, 150, and 180 (EOT, End of Trial) days after randomisation. Only visits at 7, 90 and 180 days after randomisation will be on-site visits, the remaining being telephone visits. If dose titration occurs at any time during the outpatient phase, unscheduled dispensation visits will be performed. Follow-up phase: - A follow-up on-site visit (end of study visit) will occur approximately 7 days after EOT. • Data will be collected at on-site visits, via telephone visits and medical chart reviews. • An adjudication committee will be involved in the study.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Must be 18 years of age or older, at the time of signing the informed consent
- •Admitted to hospital (inpatient care; directly or from ED)
- •Diagnosed CKD (any stage) or
- •eGFR \< 90 ml/min/1.73 m2 at, or within 3 months of, study screening, based on the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation (Levey et al, 2009).
- •Note: Race/ethnicity should not be included in CKD-EPI equation calculation.
- •Local laboratory K+ measurement within 24 hours of baseline visit (visit 2), where result is either:
- •Hyperkalaemic as defined by site's local practice and K+ ≤ 6.5 mmol/L.
- •Or, normokalaemic: K+ between ≥ 3.5 and ≤ 5.0 mmol/L, where patient started and is receiving treatment for this episode of HK
- •Male or female
- •Capable and willing of giving signed informed consent as described in Appendix A which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and in this protocol.
Exclusion Criteria
- •Hospitalisation for an acute cardiovascular event within 12 weeks prior to screening
- •Unable to take oral SZC drug mix
- •With a life expectancy of less than 6 months
- •Any medical condition that, in the opinion of the investigator makes the participant not suitable for inclusion
- •QT interval corrected by the Fridericia method (QTcF) \> 550 msec
- •History of QT prolongation associated with other medications that required discontinuation of that medication
- •Congenital long QT syndrome
- •Clinically significant arrythmias as judged by the investigator
- •Ongoing treatment with SZC or patiromer before current ED visit/hospital admission (ongoing treatment with other K-binders before current ED visit/hospital admission is allowed).
- •Note: Initiation of any SZC or patiromer during the current ED visit/hospitalisation preceding enrolment is allowed.
Arms & Interventions
Sodium Zirconium Cyclosilicate (SZC)
Participants discharged with SZC, as per local label, to manage HK until the end of the outpatient phase
Intervention: Sodium Zirconium Cyclosilicate (SZC)
Local standard of care (SoC)
Participants discharged with SoC, as per local practice, to manage HK until the end of study.
Intervention: Local standard of care
Outcomes
Primary Outcomes
Occurrence (Yes/No) of NK (K+ Between 3.5 and 5.0 mmol/L, Inclusive) at 180 Days Post-discharge
Time Frame: At 180 days post-discharge (Visit 10)
A response was defined as a participant having serum K+ within 3.5 and 5.0 mmol/L at 180 days post-discharge. No response was defined as a participant who: 1) used rescue therapy for hyperkalaemia (HK) during the outpatient period; 1) died prior to 180 days post-discharge; 3) were missing an assessment at visit 10; 4) were lost to follow-up prior to 180 days post-discharge; 5) down-titrated (or discontinued) RAASi. The number of participants who had a response/no response is presented.
Secondary Outcomes
- Time to First Occurrence of Any Component of All-cause Hospital Admissions or ED Visits With HK as a Contributing Factor, or All-cause Death, or Use of Rescue Therapy for HK at Any Time Post-discharge up to 180 Days(At any time post-discharge (from Visits 4 to 10), up to 180 days)
- Time to First Occurrence of Any Component of All-cause Hospital Admission or ED Visit With HK as a Contributing Factor at Any Time Post-discharge up to 180 Days(At any time post-discharge (from Visits 4 to 10), up to 180 days)
- Number of All-cause Events (Hospital Admissions or ED Visits) With HK as a Contributing Factor at Any Time Post-discharge up to 180 Days(At any time post-discharge (from Visits 4 to 10), up to 180 days)
- Time to First Occurrence of RAASi Down-titration (or Discontinuation) at Any Time Post-discharge up to 180 Days(At any time post-discharge (from Visits 4 to 10), up to 180 days)
- Time to First Occurrence of Hospital Admission or ED Visit, Both With HK as a Contributing Factor at Any Time Post-discharge up to 180 Days(At any time post-discharge (from Visits 4 to 10), up to 180 days)
- Number of Events (Hospital Admissions or ED Visits) With HK as a Contributing Factor, at Any Time Post-discharge up to 180 Days(At any time post-discharge (from Visits 4 to 10), up to 180 days)