Use of Nitazoxanide and Probiotics in Acute Diarrhea Secondary to Rotavirus
Not Applicable
Completed
- Conditions
- DiarrheaRotavirus Infection
- Interventions
- Registration Number
- NCT00683982
- Lead Sponsor
- Centro Pediatrico Albina de Patino
- Brief Summary
Nitazoxanide has proved an cytoprotective effect against rotavirus infection. How it could be clinically important in time of hospitalization and reduction of duration of diarrhea secondary to rotavirus?
- Detailed Description
Nitazoxanide has demonstrated a cytoprotective effect against rotavirus, reducing duration time of diarrhea in comparison to placebo in previous studies. In the current study, based in those results, we design a randomized single-blind controlled trial, in order to asses the effectiveness of nitazoxanide and probiotics in comparison with a control group
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 75
Inclusion Criteria
- Positive stool sample for rotavirus test
Exclusion Criteria
- Severe malnourishment
- Severe dehydration
- History of diarrhea more than 3 days previous hospitalization
- Use of antibiotics, probiotics or nitazoxanide 3 weeks before admission
- Systemic infections
- Severe chronic disease
- Mixed enteric infections besides rotavirus
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 2 Probiotic mix preparation This group will receive a mix combination of probiotics 3 Oral hydration solutions This is the control group receiving only oral or systemic hydration solutions 1 Nitazoxanide This group will receive oral nitazoxanide preparation
- Primary Outcome Measures
Name Time Method Duration of diarrhea Hours
- Secondary Outcome Measures
Name Time Method Duration of hospitalization hours
Trial Locations
- Locations (1)
Centro Pediatrico Albina Patiño
🇧🇴Cochabamba, Bolivia