ACTRN12615000273583
Completed
Phase 4
In adults and children undergoing renal transplantation, does dose individualisation of Mycophenolate Mofetil based on a pre-transplant free MPA pharmacokinetic assessment improve post-transplant drug exposure, compared to post transplant exposure on standard fixed doses - as assessed by an increased proportion of patients within therapeutic range from early (day 3-5) post transplant in the dose individualised group, and again at 2 weeks and 3 months post transplant.
Overview
- Phase
- Phase 4
- Intervention
- Not specified
- Conditions
- End-stage kidney disease
- Sponsor
- Murdoch Children's Research Institute
- Enrollment
- 56
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Child and adult participants at or near end\-stage kidney disease (ESKD), working up to renal transplantation.
Exclusion Criteria
- •\-Renal transplant protocols not including mycophenolate mofetil
- •\-Adult ESKD patients on the cadaveric waiting list deemed unlikely to receive a transplant offer within a 2 year window.
Outcomes
Primary Outcomes
Not specified
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