The effect of Alendronate on symptoms of knee osteoarthritis
- Conditions
- Knee osteoarthritis.Gonarthrosis
- Registration Number
- IRCT138803271479N2
- Lead Sponsor
- Vice Chancellor for Research, Mashhad University of Medical Science
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 39
fulfilling the American College of rheumatology (ACR) criteria of primary knee osteoarthritis, radiologically ascertained grade I or II severity of OA of the knee on the Kellgren-Lawrence scale, having a Western Ontario and McMaster Universities (WOMAC) pain subscale index of at least 2 at baseline (the 5-point Linkert version of the WOMAC), presence of daily knee pain for at least 6 months preceding the study
Exclusion criteria: Presence of secondary osteoarthritis, arthroscopy or surgery of target knee within 6 months prior to study, intra-articular treatment of target knee within 6 months prior to study, other chronic inflammatory processes, previous gastrointestinal problems (such as gastroesophageal reflux or esophageal stricture), previous allergic reactions to bisphosphonates, presence of any risk factors for osteoporosis
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Reduction in symptoms of knee osteoarthritis. Timepoint: Weeks 0, 4, 12, 24. Method of measurement: WOMAC Index.
- Secondary Outcome Measures
Name Time Method Joint space narrowing. Timepoint: weeks 0 and 24. Method of measurement: Knee X-ray.