Comparison of 2 group of anaesthetic drugs,propofol-ketamine and propofol- dexmedetomidine to provide general anaesthesia and observe & compare change in vitals like blood pressure , heart rate and recovery profile like emergence, orientation time in patients undergoing laparoscopic cholecystectomy
Phase 3
- Conditions
- Health Condition 1: - Health Condition 2: K802- Calculus of gallbladder without cholecystitis
- Registration Number
- CTRI/2020/10/028483
- Lead Sponsor
- Jawaharlal Nehru hospital and research centre
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
ASA I and ASA II
Both genders
Age from 18 years to 60 years
Patients undergoing laparoscopic cholecystectomy
Exclusion Criteria
Age below 18 years and above 60 years
ASA III and ASA IV
Pregnant or breast - feeding patient
Patients with baseline heart rate less than 55/minute
Patients with hypertension, heart blocks and ischemic heart diseases
Allergic to study drugs
Laparoscopic cholecystectomy converted to open cholecystectomy
Patient with severe hepatic, renal, endocrine and cardiac dysfunction
Patient refusal to participate in the study
Patients on sedatives, psychiatric medications, opioid therapy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Which among the two drug combination has better hemodynamic stability and recovery characteristics. Comparison in terms of Intraoperative hemodynamic variables including heart rate , mean arterial blood pressure , systolic blood pressure, diastolic blood pressure and Recovery characteristicsTimepoint: Intraoperative heart rate , mean arterial blood pressure , systolic blood pressure, diastolic blood pressure measured every 10 mins interval . Recovery characteristics including emergence time, response to commands time, orientation time, Ramsay sedation score at 0min 30 min 60 min 90 min 120 min; VAS score at 0 hour ,1 , 2, 3, 4, 6, 8,10, 12, 18, 24th hour; first analgesic time; recovery discharge
- Secondary Outcome Measures
Name Time Method Hemodynamics , Recovery profile, post operative analgesic requirement, PACU stayTimepoint: Intraoperative hemodynamic variables like heart rate , mean arterial blood pressure every 10 mins interval . Recovery characteristics including emergence time, response to commands time, orientation time, Ramsay sedation score at 0min 30 min 60 min 90 min 120 min; VAS score at 0 hour ,1 , 2, 3, 4, 6, 8,10, 12, 18, 24th hour; first analgesic time; recovery discharge