NCT05916989已完成不适用
Stimulant Use and Methylation in HIV
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 53
- 试验地点
- 1
- 主要终点
- Neuroimmune Signaling
研究概览
简要总结
This study will leverage extracted leukocyte DNA specimens from a completed NIH-funded project to examine the efficacy of a behavioral intervention model that reduced stimulant use on DNA methylation over 6 months.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •At least 18 years old
- •Documentation of HIV-positive serostatus
- •Speak English
- •Biological verification of recent methamphetamine use
- •Completion of at least three contingency management (CM) visits
- •Self reported anal sex with a man in the past 12 months
排除标准
- •Inability to provide informed consent, evidenced by cognitive impairment
- •HIV negative serostatus
结局指标
主要结局
Neuroimmune Signaling
时间窗: 6 Months
Decreased methylation of genes for genes relevant to neuroimmune signaling such as beta-2 (β2) adrenergic (i.e., ADRB2), glucocorticoid (i.e., NR3C1 and FKBP5), and oxytocin (i.e., OXTR) receptors as well as brain-derived neurotrophic factor (BDNF) promoters.
次要结局
- DNA Methylation Pathways(6 Months)
- Immune Dysfunction(6 Month)
- Dysregulated Metabolism of Amino Acid Precursors for Neurotransmitters measured via high-performance liquid chromatography (HPLC)(6 Months)
研究者
Adam Carrico, PhD
Professor and Chair
Florida International University
研究点 (1)
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