Efficacy of Adding Dexmedetomidine to Bupivacaine in Ultrasound-guided Erector Spinae Plane Block for Postoperative Analgesia After Laparoscopic Cholecystectomy: A Prospective Randomized Trial
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- postoperative morphine consumption
研究概览
简要总结
Sixty patients scheduled for elective laparoscopic cholecystectomy will be randomly assigned using sealed envelope into two equal groups (30 patients each).
Group 1: will receive bilateral ESP block with injection of 20 ml of 0.25% Bupivacaine in each site of injection .
Group 2: will receive bilateral ESP block with injection of 18ml of 0.25% Bupivacaine plus 2ml dexmedetomidine 0.5 ug /kg in each site of injection .
详细描述
This prospective randomized study will be carried out in general surgery Department within 6 months from January 2022 to June 2022 on the 60 patients scheduled for elective laparoscopic cholecystectomy . A written informed consent will be obtained from the patients. Every patient will receive an explanation to the purpose of the study and will have a secret code number and the photos applied only to the part of the body linked to the research to ensure privacy to participants and confidentiality of data.
Research results will be only used for scientific purposes. Procedures will be approved by both the Institutional and the Regional ethical committees.
The risk that may occur is minimal, inadequate analgesia and this risk will be overcome by tramadol 50 mg intravenously STAT dose. Any unexpected risk appears during the course of the research will be cleared to the participants and ethical committee on time and proper measures will be taken to overcome or minimize these risks.
The research end point when reach desired lower pain score postoperative without occurance of any complication as heamodynamic instability.
. Preanesthetic checkup and routine investigations, such as complete blood count test, liver &kidney function test and coagulation profile, will be done. Patients will be kept fasting for 8 h.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Double (Investigator, Outcomes Assessor)
盲法说明
both investigator and outcome assessor do not know in which group is the patient
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- •patients who refuse to give written informed consent
- •sever respiratory or cardiac disorder
- •coagulopathy
- •local infection at injection site
- •spine or chest wall deformity
- •patients with known allergy to the drugs used
研究组 & 干预措施
group 1
Group 1: will receive bilateral ESP block with injection of 20 ml of 0.25% Bupivacaine in each site of injection .
干预措施: Bupivacain only (Drug)
group 2
Group 2: will receive bilateral ESP block with injection of 18ml of 0.25% Bupivacaine plus 2ml dexmedetomidine 0.5 ug /kg in each site of injection .
干预措施: dexmedetomidine as adjuvant with bupivacaine (Drug)
结局指标
主要结局
postoperative morphine consumption
时间窗: first 24 hours
the total amount of morphine consumption in the first 24-hour postoperative
次要结局
未报告次要终点
研究者
Wafaa Madhy Atia Abdelwahed
principle investigator
Tanta University