Ewing’sSarcoma with Intradural Involvement: An Ambispective Study

Ewing’s sarcoma is a bone and soft tissue tumour commonly seen in children and young adults. Ewing’s sarcoma is primarily treated with a combination of chemotherapy and local therapy, which includes surgery and/or radiation therapy. About 20% of these tumours arise in extra-osseous sites, out of which 1-2% of tumours are dural-based lesions.Unlike peripheral PNETs, meningeal Ewing’s sarcomas are locally invasive and have a higher propensity for haematogenous spread to lungs and bone marrow. Among Ewing’s sarcoma, there is a possibility that meningeal Ewing’s sarcoma may behave differently as compared to other extraosseous sites. The recurrence rate in these cases ranges from 40-60%, distant craniospinal axis failure was reported in 41.2%, and two-year survival rates in the range of 30-60%.Owing to the rarity of meningeal Ewing’s sarcomas, the management protocol of these tumours is non-uniform, with few reports of craniospinal radiotherapy at presentation. There is a lack of definite uniform data on its patterns of relapse, outcomes, and underlying demographic characteristics. This ambispective study aims to contribute to the existing literature on meningeal Ewing’s sarcoma by understanding the clinical demographics, patterns of failure, outcomes and prognostic factors; thereby improving clinical decisions and facilitating improved treatment approaches.