Assessment of Bone Quality by Microindentation in Patients with Bone Diseases

Completed

• Conditions: nvt; 10033949; 10017322

• Registration Number: NL-OMON43830
• Lead Sponsor: Endocrinologie

Brief Summary

Trial is onging in other countries

Detailed Description

Not available

Study Timeline

• Study Completion: 2018-12-01
• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 214

Inclusion Criteria

>18 years with osteoporosis, osteopenia, with and without fractures or normal bone mass with fractures or metabolic bone diseases

Exclusion Criteria

* Active infection of the measurement site.
* Recent fracture of the tibia

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Main study parameters/endpoints: Compare the validity of microindentation<br /><br>measurements with that of BMD measurements as predictor for bone strength as<br /><br>translated by prevalent fractures in the case of patients with osteoporosis</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>.to evaluate the ability of BMT measurements in patients treated with<br /><br>Bisphosphonates, particularly in the longterm, and to predict the role of local<br /><br>increasement in bone turnover in altering bone quality in localised bone<br /><br>diseases such as Paget disease of bone and fibrous dysplasia. </p><br>