Precision Medicine for Colorectal Cancer Liver Metastasis Guided by Multi-omics Data Under the Umbrella Theory
试验速览
- 阶段
- 不适用
- 入组人数
- 200
- 主要终点
- Objective response rate
研究概览
简要总结
In order to more accurately discover the cause of drug resistance in tumor treatment, and to provide a new basis for precise treatment.
Therefore, based on the umbrella theory of precision medicine, we carried out this single-center, prospective, and observational study to include patients with liver metastases from colorectal cancer. By combining genome, transcriptome, and proteomic sequencing data, we established a basis for colorectal cancer liver Transfer the multi-omics data of the sample, describe the reason for the resistance of the first-line treatment, and search for new therapeutic targets.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ECOG score 0-2 points
- •Pathologically diagnosed patients with colorectal cancer
- •Combined with liver metastases confirmed by imaging, and the lesion is measurable (RECIST standard)
- •The lesion is available
- •First-line treatment failed; hematology, liver and kidney function tests are suitable for back-line treatment
- •Informed consent
排除标准
- •With brain metastases
- •History of other malignancies
- •Pregnancy or breastfeeding
- •Have received other drug clinical studies within 30 days before the start of this study
结局指标
主要结局
Objective response rate
时间窗: 1 year
Refers to the proportion of patients whose tumors have shrunk to a certain amount and maintained for a certain period of time, including complete remission (CR) and partial remission (PR) cases
次要结局
- progression-free survival(1 year)
- Overall survival(3 years)