Effects of Light on Melatonin and Contractions in Pregnant Women
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 51
- 试验地点
- 1
- 主要终点
- Melatonin Area Under the Curve (AUC)
研究概览
简要总结
Specific Aim: Test the hypothesis that ocular light exposure will suppress melatonin secretion and reduce uterine contractions in women at late term pregnancies.
Secondary aim. Test the hypothesis that ocular light exposure will reduce self-reported uterine contractions in women at late term pregnancies.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •pregnant at 35-40 weeks
- •first pregnancy
排除标准
- •pregnancy-related complications
- •twin or higher pregnancy
- •using medication that affects the sympathetic nervous system
研究组 & 干预措施
Lighting2
Ocular light exposure of a blue-green wavelength light for one night
干预措施: Lighting2 (Device)
Lighting3
Ocular light exposure to a red wavelength light on night 1 and to a red wavelength light on night 2
干预措施: Lighting1 (Device)
Lighting1
Ocular light exposure of a red wavelength light for one night
干预措施: Lighting1 (Device)
Lighting4
Ocular light exposure to a red wavelength light on night 1 and to a blue-green wavelength light on night 2
干预措施: Lighting1 (Device)
Lighting4
Ocular light exposure to a red wavelength light on night 1 and to a blue-green wavelength light on night 2
干预措施: Lighting2 (Device)
结局指标
主要结局
Melatonin Area Under the Curve (AUC)
时间窗: 4 hours of light exposure.
Melatonin will be assessed using concentrations in saliva or blood. AUC will be calculated using melatonin concentrations during the Outcome Measure Time Frame. (1) for Lighting1 and Lighting2, the AUC for night 1; (2) for Lighting3 and Lighting4, the AUC for Night 2
次要结局
- Uterine Contractions(4 hours of light exposure)
研究者
Elizabeth Klerman MD PhD
Associate Professor
Brigham and Women's Hospital