Prognostic value of prothrombin time - international normalised ratio to albumin ratio in patients with sepsis

NEED FOR THE STUDY

Liver is a key integrator of microbial response and is a target organ during sepsis. An early and accurate assessment of liver function is critical in patients with sepsis and monitoring of hepatic dysfunction can serve as an independent predictor of mortality in sepsis. Several studies have shown that prothrombin time–international normalized ratio to albumin ratio showed good discrimination ability for predicting mortality and served as a convenient and practical tool for predicting prognosis of critically ill patients. Higher prothrombin time–international normalized ratio to albumin ratio are associated with greater risk for liver cirrhosis, post-operative liver failure and worse patient prognosis.

 DESCRIPTION

Patients will be selected based on the above inclusion exclusion criteria and recruited into the study after taking written informed consent. Prothrombin time–international normalized ratio to albumin ratio (PTAR Score) will be calculated and the patients will be divided into High, Intermediate and Low PTAR scores.

Data about the patient’s requirement for Mechanical Ventilation, Inotropic support and Hemodialysis will be collected.

Acute Physiology and Chronic Health Evaluation (APACHE II) Score will be calculated.

The collected data will be tabulated and analysed. The data will be recorded in MS Excel spreadsheet and statistics will be elaborated in the form of means/standard deviations and medians/IQRs for continuous variables, and frequencies and percentages for categorical variables.

Linear correlation between two continuous variables will be explored using Pearson’s correlation and Spearman’s correlation.