Analysis of the Role of T-cell Response in Patients With Atrial Fibrillation for Clinical Application
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Atrial Fibrillation
- Sponsor
- Yonsei University
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- The frequency (%) of specific marker-expressing cells among CD4 or CD8 T-subsets
- Last Updated
- 7 years ago
Overview
Brief Summary
The purpose of this study is 1) to characterize T-cell response in patients with atrial fibrillation, and 2) to analyze the changes of T-cell response after radio-frequency catheter ablation of atrial fibrillation. First, immune-phenotyping and cytokine profiling of T cells from patients with atrial fibrillation will performed. Next the difference of T-cell immunity among various type of atrial fibrillation patients will be analyzed. Finally the changes of T-cell response and cytokines after radio-frequency catheter ablation of atrial fibrillation will be assessed.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients who consent with study
- •patients with age more than19
- •patients who undergoing catheter ablation of atrial fibrillation due to symptomatic, drug refractory atrial fibrillation
Exclusion Criteria
- •Patients who do not agree with study inclusion
- •Permanent AF refractory to electrical cardioversion
- •AF with rheumatic valvular disease
- •Patients with left atrial diameter greater than 60mm
- •Patients with age less than 19
- •Patient with malignant tumor and chronic infection disease
- •Patient are given immune inhibitor and steroidal anti-inflammatory drug within 2weeks
Outcomes
Primary Outcomes
The frequency (%) of specific marker-expressing cells among CD4 or CD8 T-subsets
Time Frame: 1 year
* Immunosenescence marker: CD28, CD57 * Activation marker: CD38, HLA-DR * Differentiation marker: CCR7, CD45RA
Secondary Outcomes
- The frequency (%) of cytokine-secreting cells among CD4 or CD8 T-subsets(1 year)