Analysis of the Role of T-cell Response in Patients With Atrial Fibrillation for Clinical Application
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- The frequency (%) of specific marker-expressing cells among CD4 or CD8 T-subsets
研究概览
简要总结
The purpose of this study is 1) to characterize T-cell response in patients with atrial fibrillation, and 2) to analyze the changes of T-cell response after radio-frequency catheter ablation of atrial fibrillation. First, immune-phenotyping and cytokine profiling of T cells from patients with atrial fibrillation will performed. Next the difference of T-cell immunity among various type of atrial fibrillation patients will be analyzed. Finally the changes of T-cell response and cytokines after radio-frequency catheter ablation of atrial fibrillation will be assessed.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who consent with study
- •patients with age more than19
- •patients who undergoing catheter ablation of atrial fibrillation due to symptomatic, drug refractory atrial fibrillation
排除标准
- •Patients who do not agree with study inclusion
- •Permanent AF refractory to electrical cardioversion
- •AF with rheumatic valvular disease
- •Patients with left atrial diameter greater than 60mm
- •Patients with age less than 19
- •Patient with malignant tumor and chronic infection disease
- •Patient are given immune inhibitor and steroidal anti-inflammatory drug within 2weeks
结局指标
主要结局
The frequency (%) of specific marker-expressing cells among CD4 or CD8 T-subsets
时间窗: 1 year
* Immunosenescence marker: CD28, CD57 * Activation marker: CD38, HLA-DR * Differentiation marker: CCR7, CD45RA
次要结局
- The frequency (%) of cytokine-secreting cells among CD4 or CD8 T-subsets(1 year)