The effect of intensive blood glucose control with insulin on markers of short and medium term outcomes in patients hospitalised with acute exacerbations of chronic lung disease. Pilot Study to test feasibility and safety of a clinical protocol for intensive blood glucose control with insulin on medical wards - Pilot of Intensive Blood Glucose Control with Insulin on Medical Wards

St George's, University of London0 个研究点开始时间: 2007年11月26日最近更新: 2012年3月19日

适应症

试验速览

暂无简介。

•- Physician diagnosis of AECOPD as primary reason for admission
•- Able to enter study within 24 hours of admission
•Cystic fibrosis
•1) CF diagnosed by 2 of: clinical features, positive sweat test, genotype;
•2) Current pulmonary exacerbation, at least 3 of: increased cough/sputum; fever; weight loss; absence from education/work due to illness; tachypnoea; new findings on chest examination; decreased exercise tolerance, decreased pulmonary function tests/oxyhaemoglobin saturation or new finding on chest radiograph [3],
•3) >18 years
•4) Admitted to hospital for intravenous antibiotics for pulmonary exacerbation.
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range

•- Intensive care unit admission
•- Moribund or not for active treatment
•- Admission expected to last <48 hours
•- Unable or unwilling to give informed consent
•- Known Type I diabetes mellitus
•- Level of English not sufficient to understand verbal and written information
•- Patients with reduced awareness of hypoglycaemia including reduced Glasgow coma scale or those taking beta blockers
•- Patients with renal or hepatic failure at increased risk of hypoglycaemia

发起方