Investigation of focal and non-focal plasticity in patients with schizophrenia.

Not Applicable

Completed

• Conditions: F20.0; Paranoid schizophrenia

• Registration Number: DRKS00009864
• Lead Sponsor: Forschungsdekanat derLudwig-Maximilians-Universität München

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2015-11-30
• Study Start: 2016-01-12
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

General inclusion criteria:
- Adults 18-45 yrs.
- Ability to understand the study information and to give written informed consent

Special inclusion criteria:
- Patients meeting the ICD-10 diagnostic criteria of schizophrenia
- duration of illness under 2 years in the case of early disease stage
- stabel medication for at least one week prior to inclusion in the study in the case of chronically ill patients
- in the case of legal supervision by a medical or social care professional written informed consent has to be given by both, the patient and the caregiver/supervisor/lawyer.

Exclusion Criteria

-Children (<18 yrs.) or adults > 45 yrs.
-Pregnancy
-Participation in an interventional study involving neuroactive medications within the last 6 months.
-Neurological disorders: diagnosis of epilepsy, severe brain injury, brain operation or brain implants, Parkinson‘s, increased intracranial pressure, TIA or stroke, subdural haematomas, infarction or haemorrhage, tumour, on-going acute or chronic infection, cerebral palsy or any other neurological deficit.
-Psychiatric disorders: Diagnosis of depression, delusional disorder, anxiety disorder, dementia, organic psychiatric illness or drug dependency (with the exclusion of tobacco dependency).
-Other severe medical conditions: Diagnosis of cardiovascular disorder, especially hypotonia or hypertension, pace maker, implanted cardioverter-defibrillator (ICD) or other implanted devices, respiratory disorders, especially asthma, chronic obstructive pulmonary disease (COPD), severe on-going , systemic skin disease (neurodermitis, psoriasis) or bone-structure involving diseases (Pagets, osteoporosis).

Special exclusion criteria for healthy controls:
any known psychiatric illness according to ICD-10 criteria. A screening using the MINI-Plus interview will be conducted.

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Completion of study and development of LTP-like plasticity (long-term-potentiation, LTP) follwoing with both interventions (PAS, tDCS) and all TMS-measurements.

Secondary Outcome Measures

Name	Time	Method
Impact of disease state on develeopment of neural plasticity.