TMS for Improving Response Inhibition in Adolescents With OCD
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 7
- 试验地点
- 2
- 主要终点
- Change in Response Time on Stop Trials of the Stop Signal Task
研究概览
简要总结
The study will examine whether inhibition of the pre-supplementary motor area (pSMA) using transcranial magnetic stimulation (TMS) normalizes activity in pSMA-connected circuits, improves response inhibition, and reduces compulsions in adolescents with OCD.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 13 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 13-18 years
- •Presence of OCD, as indicated by score on the Children's Yale-Brown Obsessive-Compulsive Scale
- •Patient and one parent speak English fluently (to ensure comprehension of study measures and instructions
- •Right-handed
- •If taking psychotropic medications, these have been stable for > 6 weeks and are expected to remain stable for the approximately 3-week study protocol
- •If currently in psychotherapy, symptom improvement has plateaued (no improvement in the past 6 weeks and symptoms expected to remain stable for the approximately 3-week study protocol)
排除标准
- •• Medical conditions contraindicated for TMS or EEG, including history of intracranial pathology, increased intracranial pressure, epilepsy or seizures, traumatic brain injury, brain tumor, stroke, implanted medical devices, possible pregnancy (female of childbearing age not using effective contraception), or any other serious medical condition (note that medical history will be reviewed by a study physician prior to TMS administration)
- •Metal in the head, except mouth (e.g., cochlear implant, implanted brain stimulators, aneurysm clips)
- •Active suicidality or psychosis
- •Existing diagnosis of Bipolar disorder, Autism Spectrum Disorder, mental retardation, or cognitive disability
- •Substance abuse or dependence
- •Taking a stimulant medication (and unwilling to forgo on study visit days)
- •Taking medication with the potential to lower seizure threshold (e.g., neuroleptics, antipsychotics)
- •Patient is a ward of the state
- •Family history of epilepsy
- •History of syncope
结局指标
主要结局
Change in Response Time on Stop Trials of the Stop Signal Task
时间窗: Change from pre (within 1 hour before) to post (within 1 hour after) intervention
Computerized task, where shorter response time (in milliseconds) indicates better performance
Change in Frontocentral P3 Amplitude on Electroencephalogram (EEG)
时间窗: Change from pre (within 1 hour before) to post (within 1 hour after) intervention
Electroencephalogram (EEG) measured amplitude on successful stop trials of the stop signal task (SST). Calculated by averaging the epochs of successful stop trials time-locked to the stop signal from the midline electrode (Cz).
次要结局
- Self-report Symptom Question(post (within 1 hour after) intervention)
研究者
Kristen Benito
Associate Professor (Research)
Bradley Hospital