NCT03628508已完成不适用
External Tibia Torsion and Passive Muscle Stiffness of Quadriceps as Two Important Contributors of Joint Loading During Walking in People With Knee Osteoarthritis
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Change of External Knee Adduction Moment as Assessed by Visual Motion Analysis System
研究概览
简要总结
Knee osteoarthritis (KOA) is a common chronic painful musculoskeletal condition among older adults. It poses great challenge to the health care system due to its inability to be cured. Understanding factors associated with disease progression in KOA should assist the development of novel prevention/rehabilitation strategies. This study investigate factors including muscle properties, lower limb alignment and joint loading in patients with knee osteoarthritis before and after a six-week exercise program.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age between 50-80
- •having radiographic tibiofemoral joint OA in the medial compartment defined as Kellgren and Lawrence grade = 2 to 3
- •having medial knee pain on most days of the month
- •having a minimum average pain score of 2 on an 11-point numerical rating scale in the past week while walking
排除标准
- •having lateral tibiofemoral compartment osteophytes greater than the medial side.
- •having undergone intra-articular corticosteroid injection or knee surgery to either knee within the past 3 months
- •having a systemic arthritic condition (e.g., rheumatoid arthritis)
- •having a knee joint replacement or high tibial osteotomy in the past
- •having any other muscular, joint or neurological condition influencing lower limb function
- •unable to walk unaided
- •having low back, hip, ankle or foot pain > 3 on numerical rating scale
- •having a body mass index (BMI) >36 kg/ m2
结局指标
主要结局
Change of External Knee Adduction Moment as Assessed by Visual Motion Analysis System
时间窗: At baseline and one week after intervention
External knee moment in the frontal plane during early stance phase of walking
次要结局
- Change of Young's Modulus of Quadriceps as Assessed by Ultrasound Elastography(At baseline and one week after intervention)
- Change of Pain Severity Score as Assessed by Knee Injury and Osteoarthritis Outcome Score(At baseline and one week after intervention)
- Tibial Torsion as Assessed by X-ray Imaging(At baseline)
研究者
研究点 (1)
Loading locations...
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