External Tibia Torsion and Passive Muscle Stiffness of Quadriceps as Two Important Contributors of Joint Loading During Walking in People With Knee Osteoarthritis
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- Change of External Knee Adduction Moment as Assessed by Visual Motion Analysis System
Study Overview
Brief Summary
Knee osteoarthritis (KOA) is a common chronic painful musculoskeletal condition among older adults. It poses great challenge to the health care system due to its inability to be cured. Understanding factors associated with disease progression in KOA should assist the development of novel prevention/rehabilitation strategies. This study investigate factors including muscle properties, lower limb alignment and joint loading in patients with knee osteoarthritis before and after a six-week exercise program.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 50 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Age between 50-80
- •having radiographic tibiofemoral joint OA in the medial compartment defined as Kellgren and Lawrence grade = 2 to 3
- •having medial knee pain on most days of the month
- •having a minimum average pain score of 2 on an 11-point numerical rating scale in the past week while walking
Exclusion Criteria
- •having lateral tibiofemoral compartment osteophytes greater than the medial side.
- •having undergone intra-articular corticosteroid injection or knee surgery to either knee within the past 3 months
- •having a systemic arthritic condition (e.g., rheumatoid arthritis)
- •having a knee joint replacement or high tibial osteotomy in the past
- •having any other muscular, joint or neurological condition influencing lower limb function
- •unable to walk unaided
- •having low back, hip, ankle or foot pain > 3 on numerical rating scale
- •having a body mass index (BMI) >36 kg/ m2
Arms & Interventions
Exercise
Six-week exercise including stretching, strengthening, endurance and gait modification
Intervention: Exercise (Other)
Outcomes
Primary Outcomes
Change of External Knee Adduction Moment as Assessed by Visual Motion Analysis System
Time Frame: At baseline and one week after intervention
External knee moment in the frontal plane during early stance phase of walking
Secondary Outcomes
- Change of Young's Modulus of Quadriceps as Assessed by Ultrasound Elastography(At baseline and one week after intervention)
- Change of Pain Severity Score as Assessed by Knee Injury and Osteoarthritis Outcome Score(At baseline and one week after intervention)
- Tibial Torsion as Assessed by X-ray Imaging(At baseline)