Standard IV Cannula Aspiration (SIVCA): A Novel, Efficient and Minimally Invasive Testicular Sperm Aspiration Technique
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 130
- 试验地点
- 1
- 主要终点
- Weight of Testicular Tissue Retrieval
研究概览
简要总结
Study question:
Can enough testicular tissue be aspirated for sperm retrieval in non-obstructive azoospermia (NOA), using a wide bore 14-G Standard IV cannula in comparison to micro-TESE?
Summary answer:
Standard IV cannula Aspiration (SIVCA) can yield an ample amount of testicular tissue sufficient for sperm retrieval through a single puncture site on the scrotum.
详细描述
What is known already:
The current conventional method of testicular sperm aspiration is fine needle aspiration (FNA). FNA has the advantage of being a cost-effective and minimally invasive procedure compared to open testicular sperm extraction (TESE). But FNA with its conventional 23-G needle may not always yield enough testicular tissue for sperm retrieval. Furthermore, FNA may require multiple punctures on the scrotum to retrieve enough tissues from different areas of the testis.
Study design, size, duration:
A 24 months prospective cohort study conducted at a specialized IVF center. A total of 130 men aged from 22 to 53 years old (35.03 +/- 9.04) with NOA and normal testicular volume (≥ 12ml) were enrolled in the study. The men had testicular biopsies taken at the day of their partners' ovum pick-up. On each patient, the testes were randomized to undergo SIVCA on one testis followed by micro-TESE on the contralateral testis.
Participants/materials, setting, methods:
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 22 Years 至 52 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Non Obstructive Azoospermia
- •Normal Sized testes (Above 12ml in volume)
排除标准
- •Obstructive Azoospermia
- •Small sized testes
结局指标
主要结局
Weight of Testicular Tissue Retrieval
时间窗: Intraoperative
If more than 0.3 grams of testicular tissue could be adequately collected from the procedure
次要结局
- Sperm Retrieval Rate(Intraoperative)
研究者
Adham ZAAZAA
Associate Professor
Cairo University