Effect of Aerobic Exercise on Inflammatory Markers in Polycystic Ovary Syndrome
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Polycystic Ovary Syndrome
- Sponsor
- Cairo University
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- Level of Interleukin 6
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
The development of Polycystic Ovary Syndrome has been linked to chronic low-grade inflammation (PCOS). In this context, the current study looked into the effects of aerobic exercise on IL6, TNF, and C-reactive protein (CRP) in PCOS women. This was a randomized clinical trial including 40 females diagnosed with PCOS who were between the ages of 25 and 35. The participants were divided into two groups, each with an equal number of individuals: aerobic exercise (AEM) and Metformin (M). At baseline and after 12 weeks of intervention, participants' levels of IL6, TNF, and CRP were measured.
Investigators
Marwa Eid
Professor of physical therapy for surgery
Cairo University
Eligibility Criteria
Inclusion Criteria
- •Mean age of 26.7 ± 2.3, body mass index (BMI) 23.6±3.5 kg/m2) .
- •confirmation by medical history of hyperandrogenic oligo amenorrhea (\<8 menses per year)
- •PCO on ultrasonography of more than 10 ovarian follicles 2-9 mm in diameter
Exclusion Criteria
- •Disorders known to cause hyperandrogenisms, such as congenital adrenal hyperplasia, thyroid dysfunction, and hyperprolactinemia.
- •Renal or hepatic dysfunction
Outcomes
Primary Outcomes
Level of Interleukin 6
Time Frame: 12 weeks
level of C- reactive protein
Time Frame: 12 weeks
Level of TNF-α
Time Frame: 12 weeks