Sarcopenia Trial: Resistance training and Oral Nutrition in the aGing (STRONG)- effect on fat free and muscle mass, strength and function in people aged 65 years and over

The University of Newcastle0 个研究点目标入组 95 人开始时间: 2018年11月26日最近更新: 2023年4月10日

试验速览

暂无简介。

•BMI >40kg/m2
•Usual dietary protein intake >1.0 g/kg BW/day
•Participation in resistance exercise (>1 wk), moderate-intensity exercise greater than or equal to 150 min/wk and/or vigorous exercise greater than or equal to 60 min/wk over the past 3 months
•Unwilling or unable to undertake resistance training exercise programme (eg severe osteoarthritis)
•Unwilling or unable to consume the study drink or cow’s milk
•Allergies or intolerance to soy (self-reported)
•Regular (>3 times per week) protein supplement (eg. Sustagen) use
•Medical conditions requiring a specialised dietary plan (eg insulin dependent diabetes)
•Current smokers (smoked within past 6 months)
•Abnormal blood chemistry panel at screening
•Chronic or excessive alcohol consumption (as evidenced by abnormal liver function tests)
•Significant weight loss (>5% BW) in the past 6 months
•Current use of systemic anti-inflammatory or immunosuppressant medications (eg corticosteroids)
•Current use of medication that may affect muscle metabolism (eg corticosteroids or thyroxine)
•Unstable cardiac condition
•Diagnosis of renal (eGFR<30) or hepatic failure; terminal illness, human immunodeficiency virus (HIV) or cognitive impairment (Mini mental state exam score <24).
•Any other medical condition which may interfere with the participant’s ability to participate in the intervention. For example a diagnosis of osteoporosis and a history of recent multiple non-trauma fractures.

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