Benefits of Enhanced Recovery After Surgery in Patients Undergoing Endoscopic Sinus Surgery
Overview
- Phase
- Not Applicable
- Intervention
- Flurbiprofen Axetil
- Conditions
- Chronic Rhinosinusitis (Diagnosis)
- Sponsor
- Beijing Tongren Hospital
- Enrollment
- 55
- Locations
- 1
- Primary Endpoint
- Pain management
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
Enhanced recovery after surgery (ERAS) protocols have been widely applied during perioperative periods for different diseases, there are few reports of ERAS in patients undergoing endoscopic sinus surgery (ESS). This study therefore aimed to evaluate the benefits of ERAS protocol compared to traditional care following ESS.
Investigators
Luo Zhang
vise president of BeijingTongren Hospital
Beijing Tongren Hospital
Eligibility Criteria
Inclusion Criteria
- •The patient has CRSwNP need endoscopic sinus surgery for treatment.
Exclusion Criteria
- •age under 18 years
- •ASA grade IV
- •received oral or topical steroids within 4 weeks preceding surgery
- •had previous ESS history
- •intolerant to NSAIDS
- •comorbidity of severe mental disease
- •not compliant with therapy.
Arms & Interventions
ERAS with postoperative intravenous Flubiprofen Axetil
The patients was given extended perioperative counseling, shorter fasting food for 6 to 8 hours and carbohydrate water for 2 hours before surgery. Early ambulation and oral intake 2 hours after patient recovery from anesthesia. Once a day 100mg Flubiprofen Axetil in this group for postoperative pain management.
Intervention: Flurbiprofen Axetil
ERAS with postoperative intravenous Flubiprofen Axetil
The patients was given extended perioperative counseling, shorter fasting food for 6 to 8 hours and carbohydrate water for 2 hours before surgery. Early ambulation and oral intake 2 hours after patient recovery from anesthesia. Once a day 100mg Flubiprofen Axetil in this group for postoperative pain management.
Intervention: Extended perioperative counseling
ERAS with postoperative intravenous Flubiprofen Axetil
The patients was given extended perioperative counseling, shorter fasting food for 6 to 8 hours and carbohydrate water for 2 hours before surgery. Early ambulation and oral intake 2 hours after patient recovery from anesthesia. Once a day 100mg Flubiprofen Axetil in this group for postoperative pain management.
Intervention: Shorter fasting food and water time before surgery
ERAS with analgesia pump
The patients was given extended perioperative counseling, shorter fasting food for 6 to 8 hours and carbohydrate water for 2 hours before surgery. Early ambulation and oral intake 2 hours after patient recovery from anesthesia. An electronic analgesic pump containing opioids drug and Flubiprofen Axetil in this group for postoperative pain management.
Intervention: Sufentanil
ERAS with analgesia pump
The patients was given extended perioperative counseling, shorter fasting food for 6 to 8 hours and carbohydrate water for 2 hours before surgery. Early ambulation and oral intake 2 hours after patient recovery from anesthesia. An electronic analgesic pump containing opioids drug and Flubiprofen Axetil in this group for postoperative pain management.
Intervention: Extended perioperative counseling
ERAS with analgesia pump
The patients was given extended perioperative counseling, shorter fasting food for 6 to 8 hours and carbohydrate water for 2 hours before surgery. Early ambulation and oral intake 2 hours after patient recovery from anesthesia. An electronic analgesic pump containing opioids drug and Flubiprofen Axetil in this group for postoperative pain management.
Intervention: Shorter fasting food and water time before surgery
Traditional care with Flubiprofen Axetil
Conventional perioperative counseling and regular fasting food for 12 hours and water for 6 hours before surgery. Lie down and oral intake at least 4 hours after recovery. Once a day 100mg Flubiprofen Axetil in this group for postoperative pain management.
Intervention: Flurbiprofen Axetil
Traditional care with Flubiprofen Axetil
Conventional perioperative counseling and regular fasting food for 12 hours and water for 6 hours before surgery. Lie down and oral intake at least 4 hours after recovery. Once a day 100mg Flubiprofen Axetil in this group for postoperative pain management.
Intervention: Conventional perioperative counseling
Traditional care with Flubiprofen Axetil
Conventional perioperative counseling and regular fasting food for 12 hours and water for 6 hours before surgery. Lie down and oral intake at least 4 hours after recovery. Once a day 100mg Flubiprofen Axetil in this group for postoperative pain management.
Intervention: Regular fasting food and water time before surgery
Traditional care with analgesia pump
Conventional perioperative counseling and regular fasting food for 12 hours and water for 6 hours before surgery. Lie down and oral intake at least 4 hours after recovery. An electronic analgesic pump containing opioids drug and Flubiprofen Axetil in this group for postoperative pain management.
Intervention: Sufentanil
Traditional care with analgesia pump
Conventional perioperative counseling and regular fasting food for 12 hours and water for 6 hours before surgery. Lie down and oral intake at least 4 hours after recovery. An electronic analgesic pump containing opioids drug and Flubiprofen Axetil in this group for postoperative pain management.
Intervention: Conventional perioperative counseling
Traditional care with analgesia pump
Conventional perioperative counseling and regular fasting food for 12 hours and water for 6 hours before surgery. Lie down and oral intake at least 4 hours after recovery. An electronic analgesic pump containing opioids drug and Flubiprofen Axetil in this group for postoperative pain management.
Intervention: Regular fasting food and water time before surgery
traditional care without postoperative intravenous analgesia.
Conventional perioperative counseling and regular fasting food for 12 hours and water for 6 hours before surgery. Lie down and oral intake at least 4 hours after recovery. Intravenous saline with necessary oral analgesic for postoperative pain management.
Intervention: Conventional perioperative counseling
traditional care without postoperative intravenous analgesia.
Conventional perioperative counseling and regular fasting food for 12 hours and water for 6 hours before surgery. Lie down and oral intake at least 4 hours after recovery. Intravenous saline with necessary oral analgesic for postoperative pain management.
Intervention: Regular fasting food and water time before surgery
Outcomes
Primary Outcomes
Pain management
Time Frame: at 48 hours after surgery
The pain scores after surgery were scored on a visual analogue scale of 0 to 10 as previously described, with 0 being no complaints whatsoever and 10 being the worst imaginable.
Secondary Outcomes
- Hunger scores(at 5 minutes before surgery start)
- Self-rating Anxiety Scale(at baseline and 72 hours after surgery)
- thirst scores(at 5 minutes before surgery start)
- General comfort scores(at baseline and 72 hours after surgery)
- quality of sleeping(at baseline and 72 hours after surgery)