Prospective, randomised, double-blind trial of heparin or 0.45% saline infusion through the long line to reduce the incidence of long line sepsis in very low birth-weight infants

St Mary's Hospital (UK)0 个研究点目标入组 128 人开始时间: 2006年5月26日最近更新: 2016年10月17日

适应症

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•Infants admitted to Winnicott Baby Unit (Neonatal Intensive Care Unit [NICU]), St Mary's Hospital and born with birth weight <1500 g and who need a long line inserted for any medical indication and for whom written parental consent has been obtained are eligible to enter the study. Each baby can be enrolled only once in the study - the same infant will not be enrolled for the study again if he/she needs another long line inserted and if he/she has already been in the study before.

•1. Infants who have a persisting haemorrhagic diathesis at time of proposed insertion of long line (LL). (International normalised ratio [INR] >1.8, activited partial thromboplastin time [APTT] >79.4 sec: Andrew M, et al 1988. Blood 72:1651-7)
•2. Infants for whom parents have refused consent
•3. Infants with birth weight =1500 g
•4. Infants who have a =grade 3 intraventricular haemorrhage, unilaterally or bilaterally (by Papille's classification)
•5. Infants with culture proven infection within 48 hours prior to long line insertion
•6. Infants with platelet counts <100 x 10^9/l
•7. Infants who are deemed clinically unstable by the attending clinician but not from getting a

发起方

St Mary's Hospital (UK)