Balance Performance and Corticomotor Inhibition in PD

• Conditions: Parkinson Disease

• Registration Number: NCT05066659
• Lead Sponsor: National Yang Ming Chiao Tung University

Brief Summary

Postural instability is one of the motor features of Parkinson's disease (PD). Most patients will develop balance dysfunction, and they may get worse with disease progression. According to previous studies, people with PD had abnormal changes in corticomotor excitability, especially disinhibition in the primary motor cortex (M1). Some evidence had shown that the cortical function in the M1 is crucial for the pathophysiology of the underlying motor symptoms in PD. Furthermore, neurostimulation over the M1 could modulate the corticomotor excitability in individuals with PD, and then improve their motor and also balance performance. However, whether the impaired corticomotor inhibition relates to balance dysfunction in people with PD is still unknown. In this study, the purpose is to investigate the possible relationship between corticomotor inhibition and balance performance in individuals with PD. However, the postural position during TMS measurement may affect the corticomotor excitability. To further establish the above-mentioned relationship, the secondary purpose is to explore and confirm whether the postural position will influence the correlation.

Detailed Description

Not available

Study Timeline

• Status Verified: 2021-09
• Study First Submitted: 2021-09-23
• Study First Submitted QC: 2021-09-23
• Last Update Submitted: 2021-09-23
• Study First Posted: 2021-10-04
• Last Update Posted: 2021-10-04
• Study Start: 2021-10-08
• Primary Completion: 2022-09-08
• Study Completion: 2022-09-08

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• the Hoehn and Yahr stage between 1 and 3
• age 40 to 80 years
• a stable treatment of anti-PD medications

Exclusion Criteria

• any contraindications of TMS
• any injury histories or disorders affecting balance
• any neurosurgery experience
• neurologic conditions other than PD
• the Mini-mental State Examination (MMSE) score < 24

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Functional balance	15 minutes	Mini-Balance Evaluation Systems Test
Intracortical inhibition	20 minutes	Short-interval intracortical inhibition assessed by transcranial magnetic stimulation
Corticospinal inhibition	20 minutes	Cortical silent period assessed by transcranial magnetic stimulation
Static balance	3 minutes	Sharpened Romberg test
Dynamic balance	5 minutes	Functional reach test

Trial Locations

Locations (1)

Department of Physical Therapy and Assistive Technology, National Yang Ming Chiao Tung University; 🇨🇳 Taipei, Taiwan