The effect of two different intraoperative inspired oxygen concentration on postoperative pulmonary atelectasis in Geriatric patients undergoing elective surgery under general anesthesia: a Randomized-Controlled Trial
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 48
- Locations
- 1
- Primary Endpoint
- To compare the incidence and severity of postoperative atelectasis determined by CT thorax.
Study Overview
Brief Summary
All patients requiring general anaesthesia need oxygen administration. Supplementing patients with high inspired oxygen is considered to have harmful effects on lung physiology and increases the chances of postoperative pulmonary complications. But recent studies suggest that there is no clinically significant difference in postoperative lung atelectasis between low and high intraoperative inspired oxygen. However, high inspired oxygen is beneficial in reducing incidence of postoperative vomiting and surgical site infection. Most of the studies have been conducted in healthy individual to our best knowledge.
So,we planned to do a randomised study on the effect of two different intraoperative inspired oxygen concentrations on postoperative pulmonary atelectasis in geriatric patients undergoing elective surgeries.
Study Design
- Study Type
- Interventional
- Allocation
- Computer generated randomization
- Masking
- Participant, Investigator, Outcome Assessor and Date-entry Operator Blinded
Eligibility Criteria
- Ages
- 60.00 Year(s) to 99.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •Patients aged more than 60 years and scheduled for elective major surgery of duration more than 2 hours under general anaesthesia will be enrolled.
Exclusion Criteria
- •1.Patient undergoing cardio-thoracic surgery, thoracotomies 2.Patients with active upper or lower airway infection 3.Patients with abnormal preoperative chest Xâ€ray findings 4.Patients who are likely to require postoperative mechanical ventilation 5.Morbidly obese patients (BMI-35Kg/m2).
Outcomes
Primary Outcomes
To compare the incidence and severity of postoperative atelectasis determined by CT thorax.
Time Frame: To compare the incidence and severity of postoperative atelectasis during postoperative period upto 24hrs determined by CT thorax.
Secondary Outcomes
- 1.To compare postoperative gas exchange by PaO2/FIO2.(before preoxygenation and postoperatively at 1-hour, 6-hours and 12-hours)
- 2.To compare incidence of postoperative nausea and vomiting.(24 hours postoperatively.)
- 3.To compare incidence of surgical site infection.(Till 5 days postoperatively.)
- 4.To compare requirement of postoperative respiratory support (oxygen supplementation/ mechanical ventilation).(Till day 3 postoperatively.)
- 5.To compare incidence of postoperative pneumonia.(Till day 3 postoperatively.)