To compare the effects of Dexmeditomidine, Esmolol, and combination of both to know the stress response prevention for endotracheal intubation.
Phase 4
- Conditions
- Health Condition 1: null- Adult patients with ASA 1and 2 physical status scheduled for cardiac surgery
- Registration Number
- CTRI/2017/11/010355
- Lead Sponsor
- Vydehi Institute of Medical Sciences and Research Centre
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Closed to Recruitment of Participants
- Sex
- Not specified
- Target Recruitment
- 120
Inclusion Criteria
Adult patients with ASA 1and 2 physical status scheduled for cardiac surgery
Exclusion Criteria
Exclusion criteria included anticipated difficult intubation, emergency surgery, left ventricular ejection fraction <40%, left ventricular aneurysm, associated valvular lesions, left main coronary artery disease, severe systemic diseases involving the renal and hepatic systems, preoperative left bundle branch block, chronic obstructive pulmonary disease and intubation attempt lasting longer than 20 seconds.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method attenuation of stress response to endotracheal intubation in terms of heart rate, blood pressure and pulmonary artery pressureTimepoint: Hemodynamic variables(heart rate,blood pressure and pulmonary pressure) were recorded baseline, after study drug, after induction before intubation and 1, 3, 5 minute after orotracheal intubation.
- Secondary Outcome Measures
Name Time Method nilTimepoint: nil