Generalized Anxiety Disorder and Panic Disorder: Differences in Clinical Manifestation and Prognosis, a Multicenter Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 290
- 试验地点
- 1
- 主要终点
- Substance misuse
研究概览
简要总结
The goal of this observational study is to compare socio-demographic and clinical features in patients affected by Generalized Anxiety Disorder (GAD) and by Panic Disorder (PD). The main questions it aims to answer are:
- which socio-demographic/clinical markers are associated to GAD or PD diagnosis?
- which factors are associated with a longer duration of untreated illness (DUI) in GAD and in PD? Participants will signed a written informed consent and socio-demographic/clinical variables will be retrospectively collected. Researchers will compare GAD and PD groups in terms of socio-demographic and clinical features, including DUI, to better characterize the two disorders and to investigate factors associated to a longer DUI.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age 18-65 years;
- •ability and willing to give informed consent;
- •fluency in Italian language;
- •diagnosis of GAD or PD according to the criteria of the Diagnostic and Statistical Manual of Mental Disorder, 5th edition.
排除标准
- •intellectual disability;
- •lack of clinical and socio-demographic information;
- •patients treated for less than three months in the outpatient clinics for the impossibility of a comprehensive collection of clinical variables.
结局指标
主要结局
Substance misuse
时间窗: Three months
Substance misuse
Dichotomous socio-demographic / clinical variables
时间窗: Three months
Multiple family history of psychiatric disorders (yes/no), pre- and post-onset psychiatric poly-comorbidities (yes/no), presence of personality disorder (yes/no), pre- and post-onset poly-substance misuse (yes/no), pre- and post-onset medical poly-comorbidities (yes/no), suicide attempts (yes/no), hospitalizations (yes/no), poly-therapy (yes/no), presence of poly-side effects (yes/no), presence of lifetime psychotherapy (yes/no)
Sex
时间窗: Three months
Sex (male/female)
Occupation
时间窗: Three months
Occupation (employed/unemployed)
Treatment
时间窗: Three months
Treatment, treatment discontinuation and side effects
Quantitative socio-demographic / clinical variables
时间窗: Three months
Age (years), age at onset (years), duration of illness (years), duration of treatment (years)
Pre-/post-onset Comorbidity
时间窗: Three months
Psychiatric and medical comorbidity
次要结局
- Duration of untreated illness (DUI) in months = time between the onset of PD and the first appropriate pharmacological treatment.(Three months)
研究者
Alice Caldiroli
Psychiatrist
University of Milano Bicocca