Generalized Anxiety Disorder and Panic Disorder: Differences in Clinical Manifestation and Prognosis, a Multicenter Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Generalized Anxiety Disorder
- Sponsor
- University of Milano Bicocca
- Enrollment
- 290
- Locations
- 1
- Primary Endpoint
- Substance misuse
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
The goal of this observational study is to compare socio-demographic and clinical features in patients affected by Generalized Anxiety Disorder (GAD) and by Panic Disorder (PD). The main questions it aims to answer are:
- which socio-demographic/clinical markers are associated to GAD or PD diagnosis?
- which factors are associated with a longer duration of untreated illness (DUI) in GAD and in PD? Participants will signed a written informed consent and socio-demographic/clinical variables will be retrospectively collected. Researchers will compare GAD and PD groups in terms of socio-demographic and clinical features, including DUI, to better characterize the two disorders and to investigate factors associated to a longer DUI.
Investigators
Alice Caldiroli
Psychiatrist
University of Milano Bicocca
Eligibility Criteria
Inclusion Criteria
- •age 18-65 years;
- •ability and willing to give informed consent;
- •fluency in Italian language;
- •diagnosis of GAD or PD according to the criteria of the Diagnostic and Statistical Manual of Mental Disorder, 5th edition.
Exclusion Criteria
- •intellectual disability;
- •lack of clinical and socio-demographic information;
- •patients treated for less than three months in the outpatient clinics for the impossibility of a comprehensive collection of clinical variables.
Outcomes
Primary Outcomes
Substance misuse
Time Frame: Three months
Substance misuse
Dichotomous socio-demographic / clinical variables
Time Frame: Three months
Multiple family history of psychiatric disorders (yes/no), pre- and post-onset psychiatric poly-comorbidities (yes/no), presence of personality disorder (yes/no), pre- and post-onset poly-substance misuse (yes/no), pre- and post-onset medical poly-comorbidities (yes/no), suicide attempts (yes/no), hospitalizations (yes/no), poly-therapy (yes/no), presence of poly-side effects (yes/no), presence of lifetime psychotherapy (yes/no)
Sex
Time Frame: Three months
Sex (male/female)
Occupation
Time Frame: Three months
Occupation (employed/unemployed)
Treatment
Time Frame: Three months
Treatment, treatment discontinuation and side effects
Quantitative socio-demographic / clinical variables
Time Frame: Three months
Age (years), age at onset (years), duration of illness (years), duration of treatment (years)
Pre-/post-onset Comorbidity
Time Frame: Three months
Psychiatric and medical comorbidity
Secondary Outcomes
- Duration of untreated illness (DUI) in months = time between the onset of PD and the first appropriate pharmacological treatment.(Three months)