Investigation of Relevant Biomarkers in Patients With Susac Syndrome
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- serological biomarkers
研究概览
简要总结
Susac Syndrome is a rare disease and the establishment of the diagnosis is often difficult. The aim of this investigation is to identify relevant biomarkers and to elucidate the pathogenesis of Susac syndrome
详细描述
Susac Syndrome is a rare disease characterized by encephalopathy, branch retinal artery occlusion and sensorineural deafness. The pathogenesis is not yet clear, an autoimmune endotheliopathy is discussed. Because of the variable and often incomplete clinical presentation, the establishment of the diagnosis is often delayed or even completely missed.
The aim of this study is to identify biomarkers that facilitate the reliable and prompt establishment of the diagnosis. Patients with a definite diagnosis of Susac syndrome and healthy subjects as controls are investigated.
Furthermore, the correlation of serological markers with structural retinal and cerebral changes will contribute to clarification of the pathogenesis of Susac syndrome.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •adult male and female patients with definite Susac syndrome or matching healthy control subjects
- •ability to provide informed consent
排除标准
- •pregnancy
结局指标
主要结局
serological biomarkers
时间窗: not defined, cross-sectional analysis
disease specific patterns of pathology in optical coherence tomography
one time optical coherence tomography
disease specific patterns of pathology on cranial MRI
one-time cranial MRI
次要结局
未报告次要终点
研究者
Jan-Markus Dörr
PD Dr. med.
Charite University, Berlin, Germany