Variation of Aortic Compliance Related to Exercise Training With or Without Supervised Sessions

Not Applicable

• Conditions: Cardiovascular Disease
• Interventions: Procedure: Exercise training with supervised sessions

• Registration Number: NCT01939080
• Lead Sponsor: University Hospital Center of Martinique

Brief Summary

Many conditions and cardiovascular diseases (including stroke) are better managed with regular exercise training. The expected effects are partial reversal of adverse effects on heart and blood vessel structure and function, improved glycemic, tension and weight control.

Physiologically, the aorta maintains low left ventricular after-load, promotes optimal sub-endocardial coronary blood flow, and transforms pulsatile into laminar blood flow. Increased aortic stiffness may ultimately contribute to left ventricular dysfunction. Regular exercise training is likely to decrease the pulse wave velocity (a measure of the aortic compliance). Some subjects seem more responsive than others, and they may not expect the same benefit of exercise training. To the best of our knowledge, this has not been explained yet.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-04
• Study First Submitted: 2013-09-03
• Study First Submitted QC: 2013-09-05
• Study First Posted: 2013-09-11
• Status Verified: 2016-08
• Last Update Submitted: 2016-08-17
• Last Update Posted: 2016-08-18
• Primary Completion: 2017-06
• Study Completion: 2018-08

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 308

Inclusion Criteria

• patients aged 50-69 years, with moderate or high cardiovascular risk

Exclusion Criteria

• any physical or medical problem liable to limit the patient' ability to perform the cardiopulmonary exercise testing or the exercise training in safe conditions.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Medical supervision	Exercise training with supervised sessions	Exercise training with supervised sessions Classics training
No medical supervision	Exercise training with supervised sessions	Exercise training without supervised sessions Classics training

Primary Outcome Measures

Name	Time	Method
Pulse wave velocity	With or without the exercise training

Secondary Outcome Measures

Name	Time	Method
Heart rate variability	within 12 weeks after exercise training

Trial Locations

Locations (2)

CHU de Pointe à Pitre; 🇬🇵 Pointe à Pitre, Guadeloupe

CHU de Fort de France; 🇲🇶 Fort de France, Martinique