The effects of different vibratory stimuli frequencies during orthodontic tooth movement on the secretion of RANKL:OPG ratio: A randomized clinical trial

Not Applicable

Completed

• Conditions: Healthy Adult patients; Vibration; Receptor Activator of Nuclear Kappa- B Ligand (RANKL); Osteoprotegerin (OPG); Orthodontic tooth movement; Tooth movement acceleration

• Registration Number: TCTR20170707004
• Lead Sponsor: Graduate School, Prince of Songkla University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-07-07
• Study Completion: 2017-12-30
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

- The patients who have malocclusion, which need the extraction of right and left upper first premolar for upper canine retraction.
- The age of patients are between 18-30 years.
- No signs and symptoms of periodontal disease follow by American academy of periodontology (AAP) 1990.
- No other bone diseases.
- No drug allergy and long term use of anti-inflammatory, immunosuppressive, bisphosphonates and steroid drugs especially 6 months before started treatment.

Exclusion Criteria

- Un-cooperative patients.
- The participants are unable to continue treatment.
- Loss follows up.
- Unable to control oral hygiene.
- Presence of periodontal diseases during study.
- Failure of bonding on the maxillary canine.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
RANKL:OPG ratio Before bracket placement(T0), Before canine retraction(T1), 24 hours(T2), 48 hours(T3), 7 days(T4), Picogram/microlite

Secondary Outcome Measures

Name	Time	Method
Rate of canine movement before canine retraction(T1) and 3 months canine retraction(T6) millimeters/month,Rate of molar movement before canine retraction(T1) and 3 months canine retraction(T6) millimeters/month,Canine angulation before canine retraction(T1) and 3 months canine retraction(T6) degree,Molar angulation before canine retraction(T1) and 3 months canine retraction(T6) degree,Canine rotation before canine retraction(T1) and 3 months canine retraction(T6) degree