ACTRN12616000951459尚未招募1 期
Feasibility and effects of inorganic nitrate in acute decompensated heart failure
适应症
试验速览
- 阶段
- 1 期
- 状态
- 尚未招募
- 入组人数
- 40
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 18 Years 至 o limit（—）
- 性别
- All
入选标准
- •Patients presenting to the emergency department within the previous 24 hours, with a provisonal diagnosis with ADHF. Diagnosis is based on at least one of: dyspnoea, orthopnoea or oedema, and one sign of: chest crackles, peripheral oedema or ascites, and/or radiological confirmation of pulmonary vascular congestion on chest radiography. BNP and the boston criteria will also be used to refute and affirm true heart failure status.
排除标准
- •Patients will be excluded if they have a pre-existing need for inotrope therapy; an eGFR <20 mL/min/1.73m2 or on renal replacement therapy (i.e. dialysis); a baseline systolic blood pressure of < 110mmHg; relevant concomitant condition [haemoglobin of less than 10.0 gm/dL, critical aortic stenosis, isolated severe right sided heart failure, respiratory failure, cirrhosis of the liver (Child Pugh class C), advanced malignancy or advanced dementia]; women of child-bearing potential or nursing mothers, recent Sildenafil use (<24 hours on specific enquiry) or a history of Glucose-6-phosphate deficiency elicited on history or medical record search.
研究者
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