Evaluation of depth and thickness in skin, subcutaneous and muscle tissue at vaccination sites in Japanese infants
- Conditions
- A
- Registration Number
- JPRN-UMIN000017591
- Lead Sponsor
- Japan Vaccine Co.,Ltd
- Brief Summary
The thickness of the epidermis was 1.44 - 1.54 mm (95% CI), and the lengths from the skin surface to the muscle fascia and bone were 11.52 - 12.28 mm (95% CI), and 25.66 - 26.93 mm (95% CI), respectively, at the anterolateral thigh. At the center of the deltoid muscle, skin thickness was similar to that at the thigh, furthermore the lengths from the skin surface to the muscle fascia and bone were 8.49 - 9.10 mm (95% CI), and 17.38 - 18.31 mm (95% CI), respectively. The lengths from the skin surface to the muscle fascia and bone were 1 - 2 mm shorter in 2-month-old infants than those in older generations. Therefore, the appropriate needle length for intramuscular injections in Japanese infants was 16 mm (5/8 inch) at any age and sites, and with 25 mm (1 inch) needles at a 90-degree angle being associated with the risk of over-penetration.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 180
Not provided
(1) infant who has an abnormality in the measurement target site. (2) infant with who investigator judges stable and circumference measurements and image inspection is difficult. (3) infant who is suffering from severe acute and chronic disease. (4) infant who has an experience of any damage in the arms or legs. (5) infant who has or experienced all of neurological or muscle disease. (6) Other, infant who investigator judges ineligible as a subject. (7) infant whose written consent form is not obtained by his/her representative's own free will.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method A
- Secondary Outcome Measures
Name Time Method