COMPARISON OF INTRATHECAL FENTANYL, DEXMEDETOMIDINE AND CLONIDINE AS ADJUVANTS TO HEAVY BUPIVACAINE FOR LOWER LIMB SURGERY IN ADULT PATIENTS

Not yet recruiting

• Conditions: Unspecified fracture of lower leg,

• Registration Number: CTRI/2023/04/051460
• Lead Sponsor: Jawaharlal Nehru Medical College AMUAligarh

Brief Summary

Spinal, epidural or combined spinal-epiduralanaesthesia are the most popular and reliable techniques for lower limbsurgery. Prolongation of intraoperative and postoperative intrathecalanaesthesia and analgesia has been achieved by addition of various adjuvantssuch as Fentanyl, epinephrine and alpha-2 agonists like clonidine anddexmedetomidine. Various clinical trials have found thatadministration of dexmedetomidine, fentanyl and clonidine  with local anaesthetics  prolonged the duration of sensory and motorblockade.

In this study we plan to compare theIntrathecal fentanyl, clonidine and dexmedetomidine as adjuvants tohyperbaric bupivacaine on onset and duration of block , time to two segmentsregressions of block and duration of spinal anaesthesia for elective lower limbsurgery in adult patients.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2023-07-04
• Study Start: 2023-12-04

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

A.S.A I & II Patients Patients planned for elective lower limb surgery under Sub-Arachnoid Block.

Exclusion Criteria

• 1)Patients with contraindications to regional anaesthesia 2)Patients with disease like diabetes ,peripheral neuropathy.
• 3)Patients with history of coexisting diseases like ischaemic heart diseases, hypertension, impaired renal functions, rheumatoid arthritis and severe liver diseases .
• 4)Patients with known allergy to local anaesthetic 5) pregnant patients, chronic alcoholics, AV Blocks, incomplete heart blocks , intake of alpha-blockers.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Duration of sensory and motor block	The duration of sensory block was defined as the time of regression of two segments in the maximum block height, evaluated by pinprick. | Duration of motor block was defined as time from which patient acheive modified bromage 3 to modified bromage 0.

Secondary Outcome Measures

Name	Time	Method
1.Onset of sensory and motor block	2.Time to two segments regressions of block

Trial Locations

Locations (1)

Jawaharlal Nehru Medical College, AMU; 🇮🇳 Aligarh, UTTAR PRADESH, India

Jawaharlal Nehru Medical College, AMU

🇮🇳Aligarh, UTTAR PRADESH, India

Umar Sherwani

Principal investigator

7417886114

sherwaniumar9@gmail.com