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Clinical Trials/EUCTR2007-000727-17-NL
EUCTR2007-000727-17-NL
Active, not recruiting
Not Applicable

Maternal, uteroplacental and fetal haemodynamic effect of Nicardipine in severe pre-eclampsia. - CORCA II

Erasmus MC0 sites10 target enrollmentMarch 1, 2007
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ConditionsHypertensive crisis in patients with severe pre-eclampsia needs to be treated to prevent maternal and fetal complications. The maternal, uteroplacental and fetal haemodynamic respose to antihypertensive treatment with Nicardipinehydrochloride will be evaluated in detail by materal echocardiography and fetal doppler ultrasound as well as by the effect on plasma Brain Natriuretic Peptide concentration (BNP) and parameters of the Renin- Angiotensin- Aldosterone system (RAAS).MedDRA version: 9.1Level: LLTClassification code 10040445Term: Severe pre-eclampsia, antepartumMedDRA version: 9.1Level: LLTClassification code 10053094Term: Doppler echocardiographyMedDRA version: 9.1Level: LLTClassification code 10045412Term: Ultrasound DopplerMedDRA version: 9.1Level: LLTClassification code 10058179Term: Hypertensive emergencyMedDRA version: 9.1Level: LLTClassification code 10038555Term: ReninMedDRA version: 9.1Level: LLTClassification code 10002491Term: Angiotensin IIMedDRA version: 9.1Level: LLTClassification code 10053406Term: Brain natriuretic peptideMedDRA version: 9.1Level: LLTClassification code 10001644Term: Aldosterone
DrugsCardene

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Hypertensive crisis in patients with severe pre-eclampsia needs to be treated to prevent maternal and fetal complications. The maternal, uteroplacental and fetal haemodynamic respose to antihypertensive treatment with Nicardipinehydrochloride will be evaluated in detail by materal echocardiography and fetal doppler ultrasound as well as by the effect on plasma Brain Natriuretic Peptide concentration (BNP) and parameters of the Renin- Angiotensin- Aldosterone system (RAAS).
Sponsor
Erasmus MC
Enrollment
10
Status
Active, not recruiting
Last Updated
14 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
March 1, 2007
End Date
TBD
Last Updated
14 years ago
Study Type
Interventional clinical trial of medicinal product
Sex
Female

Investigators

Sponsor
Erasmus MC

Eligibility Criteria

Inclusion Criteria

  • •severe pre\-eclampsia
  • •sigleton pregnancy between 23 and 35 weeks
  • •admission in High Care obstetric ward
  • •intra\-arterial blood pressure registration
  • •systolic blood pressure \>\= 160 mmHg or diastolic blood pressure \>\= 110 mmHg
  • •Are the trial subjects under 18? no
  • •Number of subjects for this age range:
  • •F.1\.2 Adults (18\-64 years) yes
  • •F.1\.2\.1 Number of subjects for this age range
  • •F.1\.3 Elderly (\>\=65 years) no

Exclusion Criteria

  • •structural cardiac anomaly
  • •contra\-indication for study medication
  • •indication for Intensive Care admission (ventilation support, dialysis, ...)

Outcomes

Primary Outcomes

Not specified

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