Virtual Kidney Check and Follow-up
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 入组人数
- 3,356
- 试验地点
- 1
- 主要终点
- The proportion of individuals who undergo screening for Chronic Kidney Disease (CKD)
研究概览
简要总结
The goal of this clinical trial is to determine the most effective way to complete population-based screening for chronic kidney disease (CKD) in First Nations adults in Manitoba. The main questions it aims to answer are:
- To identify chronic kidney disease in First Nations adults in Manitoba
- To risk stratify patients as low, moderate and high risk of kidney failure and organize active surveillance by risk category
- To initiate treatments to prevent to progression of chronic kidney disease in individuals at risk of kidney failure
Participants will be randomized to:
- Patient contact via mail with a letter and laboratory requisition for serum creatinine and urine Albumin Creatinine Ratio
- Patient and primary care network contact via mail with a letter but no laboratory requisition
The primary outcome is the difference between groups in the proportion of individuals who undergo screening for chronic kidney disease within 6 months.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Screening
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age>= 18 years
- •Resident of Manitoba
- •First Nations
- •Urban, rural or remote location
排除标准
- •Kidney failure (dialysis or transplant)
- •chronic kidney disease (estimated Glomerular Filtration Rate <60 milliliter/1.73square meter for 3 months)
- •Screening for chronic kidney disease with estimated Glomerular Filtration Rate or Albumin to Creatinine ratio in the last 2 years
研究组 & 干预措施
Patient contact via mail with a letter and laboratory requisition
Patient contact via mail with a letter and laboratory requisition for serum creatinine and urine albumin to creatinine ratio
干预措施: population-based screening for chronic kidney disease (Other)
Patient and primary care network contact via mail with a letter but no laboratory requisition
干预措施: population-based screening for chronic kidney disease (Other)
结局指标
主要结局
The proportion of individuals who undergo screening for Chronic Kidney Disease (CKD)
时间窗: 6 months
The proportion of individuals screened for Chronic Kidney Disease using one screening strategy is compared to the proportion of individuals screened using the other screening strategy.
次要结局
- Number of individuals with 40 % decline in estimated Glomerular Filtration Rate(5 years)
- Hospitalizations for diseases(5 years)
- Change in estimated Glomerular Filtration Rate, urine albumin to creatinine ratio, kidney failure risk equation measurements(5 years)
- Number of individuals with kidney failure(5 years)
- Statins treatment(5 years)
- Anti-platelet agents treatment(5 years)
- The number of antihypertensive medications(5 years)
- Anti-hyperintensive therapy(5 years)
- Renin angiotensin aldosterone inhibitor blockade treatment(5 years)
- New diagnosis of CKD (Chronic Kidney Disease)(5 years)
- Sodium Glucose Cotransporter 2 (SGLT2) inhibition treatment(5 years)
- Mineral corticoid receptor antagonist treatment(5 years)
- estimated Glomerular Filtration Rate slope(5 years)
- Number of individuals on dialysis(5 years)
- Number of individuals to receive kidney transplant(5 years)
- Number of individuals who have died(5 years)