A Multicenter RegIstry on the Diagnosis of Patients with Chronic Angina and No Angiographic CoRonary Artery Stenosis (international Retrospective Collection of Anonymized Patient Data) - Searching a New Ach Spasm Definition
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- Identification of endotypes of coronary vasomotor function
研究概览
简要总结
The MICRO-SNAPE registry will collect data from patients undergoing investigation of microvascular dysfunction and coronary spasm in Europe and North America.
详细描述
Microvascular dysfunction is an important determinant of patients´quality of life and prognosis, which however remains poorly classified. Given the high burden of disease and the severity of the functional impairment in these patients, the lack of a clear understanding and diagnosis has a potentially large clinical importance. It is therefore important to better describe the phenotype of these patients. The MICRO-SNAPE registry will allow investigating these associations. Patient data as collected during the local clinical practice and at the operator's discretion, will be retrospectively entered in this non-interventional registry in anonymous form.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who underwent combined measurements of coronary pressure and flow in at least 1 native coronary artery in response to endothelium dependent and independent vasodilators.
排除标准
- •Hemodynamic instability
- •Age <18 years
结局指标
主要结局
Identification of endotypes of coronary vasomotor function
时间窗: immediately after the invasive measurement
Patients will be classified in different endotypes according to the pattern of their responses to endothelium-dependent and independent vasodilators.
次要结局
- Accuracy of clinical criteria for the diagnosis of microvascular and epicardial spasm(immediately after the invasive measurement)
- Normal values expressing endothelium-dependent coronary flow reserve(immediately after the invasive measurement)
- Sex impact on coronary vasospasm measures(immediately after the invasive measurement)
- Coronary bridge and epicardial spasm(immediately after the invasive measurement)
- Acetylcholine versus adenosine responses(immediately after the invasive measurement)
- Normal values and associations of resting microvascular resistances(Immediately upon measurment)
研究者
Tommaso Gori
Professor
Johannes Gutenberg University Mainz