Exercise Effects on Cardiovascular Risk Factors, Quality of Life, Muscle Function in Type 2 Diabetes and Healthy Persons

Not Applicable

• Conditions: Type 2 Diabetes; Impaired Glucose Tolerance
• Interventions: Behavioral: Exercise

• Registration Number: NCT00852982
• Lead Sponsor: Karolinska Institutet

Brief Summary

A sedentary lifestyle is known to be a risk factor to developing type 2 diabetes. The aim of this study was to determine the effects of adding regular Nordic walking to daily physical activity. Effects on quality of life, cardiovascular risk factors and functions in muscle cells will be determined.

Detailed Description

Regular physical activity is known to have a beneficial effect on several factors affecting the risk of developing cardiovascular disease and type 2 diabetes. Implementing and maintaining changes of lifestyle is, however, known to be difficult. In this study we wished to investigate the effects of an exercise intervention that is feasible to most people with type 2 diabetes or at risk of developing that disease. The intervention was Nordic walking (with walking poles) for five hour per week, during four months. We chose to determine effects on health related quality of life, clinical parameters related to body weight/body composition, blood pressure, glucose metabolism, insulin resistance, blood lipids, oxygen uptake and physiological effects in skeletal muscle cells related to glucose metabolism.

On inclusion and after four months the participants were therefore subject to clinical measurements, blood samples, maximal oxygen uptake tests on an ergometer cycle and muscle biopsies at inclusion and after four months of participation. They also answered an extensive questionnaire focusing on health related quality of life.

Study Timeline

• Study Start: 2006-04
• Status Verified: 2009-02
• Study First Submitted: 2009-02-26
• Study First Submitted QC: 2009-02-26
• Study First Posted: 2009-02-27
• Last Update Submitted: 2009-02-27
• Last Update Posted: 2009-03-02
• Primary Completion: 2009-09
• Study Completion: 2009-09

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 213

Inclusion Criteria

• BMI>25

Exclusion Criteria

• Physical impairment
• Symptomatic angina pectoris
• Insulin treatment

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Exercise	Exercise	Five hours of Nordic walking per week, during four months
Control	Exercise	Control group asked not to alter lifestyle during study

Primary Outcome Measures

Name	Time	Method
HbA1c	at inclusion and after four months

Secondary Outcome Measures

Name	Time	Method
waist circumference	at inclusion and after four months

Trial Locations

Locations (1)

Primary health care center; 🇸🇪 Stockholm, Sweden