CTRI/2025/11/097913招募中不适用
Effect of different doses of Magnesium Sulphate in adductor canal block on postoperative pain in elderly patients undergoing Total knee arthroplasty: a randomized prospective double blind study
AIIMS DELHI1 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2025年12月7日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- To compare the time to first breakthrough pain (time to first request for rescue analgesia) in the different doses of Magnesium Sulphate (125 mg, 250 mg, 500 mg, and 1 g) as an adjuvant to ropivacaine in Adductor canal block
研究概览
简要总结
The knee replacement patients have severe postoperative pain and need good analgesia, multimodal analgesia is required. Proving block would help them a lot. Adding magnesium in the block would prolong the analgesia but dose is not defined in any of the studies. Thus, we want to compare the different doses of magnesium which prolong the effect of block with minimal side effects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant, Investigator and Outcome Assessor Blinded
入排标准
- 年龄范围
- 60.00 Year(s) 至 99.00 Year(s)（—）
- 性别
- All
入选标准
- •ASA physical status I–III
- •Scheduled for elective unilateral primary TKA
- •Able to understand pain scoring and give informed consent.
排除标准
- •Allergy to study drugs
- •Chronic opioid use or neuropathic pain
- •Neuromuscular disorders
- •Local infection at injection site
- •Severe hepatic/renal dysfunction or cognitive impairment.
结局指标
主要结局
To compare the time to first breakthrough pain (time to first request for rescue analgesia) in the different doses of Magnesium Sulphate (125 mg, 250 mg, 500 mg, and 1 g) as an adjuvant to ropivacaine in Adductor canal block
时间窗: 2,4,6,12,24 hours
次要结局
- • VAS scores (0–10) at rest and during 45° knee flexion at 2, 6, 12, 24, and 48 hours postoperatively(• Total opioid consumption 0.5 mg /kg fentanyl in first 48 hours)
研究者
Neha Garg
All India Institute Of Medical Sciences, Delhi, India
研究点 (1)
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