Molecular Analysis of Thrombocytopenia and Cancer (MATAC): Investigating Antigenic Mimicry Between Platelets and Tumor Cells in Patients With Immune Thrombocytopenia (ITP) Associated With Cancer
- Conditions
- Immune ThrombocytopeniaImmune Thrombocytopenic PurpuraCancerNeoplasms
- Interventions
- Other: ITP and cancer
- Registration Number
- NCT06444477
- Lead Sponsor
- University Hospital, Bordeaux
- Brief Summary
The association between hematologic malignancies and ITP is well described, but this link is much less clear with solid cancers. In cases of ITP associated with cancers, specific cancer treatment can lead to remission or even cure of ITP. Thus, our hypothesis was that chronic expression of GPIIB by tumor cells could have initiated an autoimmune loop against GPIIB, leading to the onset and perpetuation of ITP.
- Detailed Description
Autoimmune thrombocytopenia, also known as immune thrombocytopenic purpura (ITP), is a rare autoimmune disease characterized by platelet destruction and impaired production, posing a life-threatening risk due to bleeding complications. The pathophysiology of ITP involves complex mechanisms, including both defective platelet production and auto-reactivity of B and T lymphocytes leading to the production of autoantibodies against platelets, found in 35 to 55% of cases. Additionally, in the context of neoplasia, some patients may develop varying degrees of thrombocytopenia, exacerbating morbidity and mortality. A multicenter, retrospective study will collect data from routine care, including birth date, gender, biological parameters related to ITP, dates of treatment initiation and diagnosis of ITP and cancer, types of treatments, and outcomes such as survival or death, without additional medical interventions or appointments.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 70
- Adult patients with a definite diagnosis of both ITP and cancer;
- Synchronous diagnosis of ITP and cancer;
- Onset of ITP occurring 6 months before or after the diagnosis of cancer.
- None
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Patients with a definite diagnosis of both ITP and cancer ITP and cancer -
- Primary Outcome Measures
Name Time Method Remission rate of ITP at 6 months after specific cancer treatment At baseline (Day 0)
- Secondary Outcome Measures
Name Time Method All-cause mortality At baseline (Day 0) Side effects related to ITP and its treatment At baseline (Day 0) Side effects related to its treatment At baseline (Day 0) Demographic description of the characteristics of ITP associated with a diagnosis of solid cance At baseline (Day 0) Clinical description of the characteristics of ITP associated with a diagnosis of solid cancer At baseline (Day 0) Biological description of the characteristics of ITP associated with a diagnosis of solid cancer At baseline (Day 0) Therapeutic description of the characteristics of ITP associated with a diagnosis of solid cance At baseline (Day 0)
Trial Locations
- Locations (20)
AP-HP Hôpital Jean Verdier service de médecine interne
🇫🇷Bondy, France
CHU de Clermont-Ferrand - service de médecine interne
🇫🇷Clermont-Ferrand, France
AP-HP Hôpital Mondor service de médecine interne
🇫🇷Créteil, France
AP-HP Hôpital Bicêtre service de médecine interne
🇫🇷Le Kremlin-Bicêtre, France
CHU de Lille - service d'Hématologie
🇫🇷Lille, France
HCL - service d'Hématologie
🇫🇷Lyon, France
AP-HM Hôpital la Timone - service de médecine interne
🇫🇷Marseille, France
CHU de Montpellier - service d'Hématologie
🇫🇷Montpellier, France
CHRU de Nancy - service de Médecine Interne et Immunologie Clinique
🇫🇷Nancy, France
CHU de Nantes - service de médecine interne
🇫🇷Nantes, France
CHRU d'Orléans - service de Médecine interne
🇫🇷Orléans, France
CHRU d'Orléans - service de réanimation
🇫🇷Orléans, France
AP-HP Hôpital Bichat service de médecine interne
🇫🇷Paris, France
AP-HP Hôpital Saint-Antoine service de médecine interne
🇫🇷Paris, France
AP-HP Hôpital Saint-Louis service immuno-hématologie
🇫🇷Paris, France
CHU de Bordeaux Service de Médecine Interne et Maladies Infectieuses
🇫🇷Pessac, France
CHU de Poitiers - service de médecine interne
🇫🇷Poitiers, France
CHRU de Strasbourg - service de médecine interne
🇫🇷Strasbourg, France
CHU de Toulouse - service de médecine interne
🇫🇷Toulouse, France
CHU de Tours - service de médecine interne
🇫🇷Tours, France