Molecular Analysis of Thrombocytopenia and Cancer (MATAC): Investigating Antigenic Mimicry Between Platelets and Tumor Cells in Patients With Immune Thrombocytopenia (ITP) Associated With Cancer
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 33
- 试验地点
- 20
- 主要终点
- Remission rate of ITP at 6 months after specific cancer treatment
研究概览
简要总结
The association between hematologic malignancies and ITP is well described, but this link is much less clear with solid cancers. In cases of ITP associated with cancers, specific cancer treatment can lead to remission or even cure of ITP. Thus, our hypothesis was that chronic expression of GPIIB by tumor cells could have initiated an autoimmune loop against GPIIB, leading to the onset and perpetuation of ITP.
详细描述
Autoimmune thrombocytopenia, also known as immune thrombocytopenic purpura (ITP), is a rare autoimmune disease characterized by platelet destruction and impaired production, posing a life-threatening risk due to bleeding complications. The pathophysiology of ITP involves complex mechanisms, including both defective platelet production and auto-reactivity of B and T lymphocytes leading to the production of autoantibodies against platelets, found in 35 to 55% of cases. Additionally, in the context of neoplasia, some patients may develop varying degrees of thrombocytopenia, exacerbating morbidity and mortality. A multicenter, retrospective study will collect data from routine care, including birth date, gender, biological parameters related to ITP, dates of treatment initiation and diagnosis of ITP and cancer, types of treatments, and outcomes such as survival or death, without additional medical interventions or appointments.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients with a definite diagnosis of both ITP and cancer;
- •Synchronous diagnosis of ITP and cancer;
- •Onset of ITP occurring 6 months before or after the diagnosis of cancer.
排除标准
- 未提供
研究组 & 干预措施
Patients with a definite diagnosis of both ITP and cancer
干预措施: ITP and cancer (Other)
结局指标
主要结局
Remission rate of ITP at 6 months after specific cancer treatment
时间窗: At baseline (Day 0)
次要结局
- Side effects related to ITP and its treatment(At baseline (Day 0))
- Side effects related to its treatment(At baseline (Day 0))
- All-cause mortality(At baseline (Day 0))
- Demographic description of the characteristics of ITP associated with a diagnosis of solid cance(At baseline (Day 0))
- Clinical description of the characteristics of ITP associated with a diagnosis of solid cancer(At baseline (Day 0))
- Biological description of the characteristics of ITP associated with a diagnosis of solid cancer(At baseline (Day 0))
- Therapeutic description of the characteristics of ITP associated with a diagnosis of solid cance(At baseline (Day 0))